COMPARING THE EFFECT OF INTRAVENOUS PULSETHERAPY WITH CONVENTIONAL ORAL STEROID-THERAPY ON THE TREATMENT OF PATIENT WITH PEMPHIGUS, BOOALI AND LOGHMAN HAKIM HOSPITALS, TEHRAN, IRAN

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SHAHIDI DADRAS M.; SHAFIEIAN S.

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:5 | Issue:4 (20) Page(s): 395-402

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Title

COMPARING THE EFFECT OF INTRAVENOUS PULSETHERAPY WITH CONVENTIONAL ORAL STEROID-THERAPY ON THE TREATMENT OF PATIENT WITH PEMPHIGUS, BOOALI AND LOGHMAN HAKIM HOSPITALS, TEHRAN, IRAN

Author(s)

SHAHIDI DADRAS M. | SHAFIEIAN S. | Issue Writer Certificate

Keywords

PEMPHIGUSQ4

PULSETHERAPYQ4

METHYLPREDNISOLONEQ3

CYCLOPHOSPHAMIDEQ4

AZATHIOPRINEQ4

AND PREDNISOLONQ3

Abstract

PEMPHIGUS is a chronic bollous life-threatening disease which has still relatively high mortality rate despite applying different therapeutic methods and significant reduction in its mortality and side-effects. Although using systemic steroid consists our treatment basis, no unique treatment has been introduced till now. In the meantime, long period of hospitalization is another weak point of common therapeutic procedures. Since 30 years ago, steroid pulse therapy has been introduced as a modem therapeutic procedure for some diseases including dermatologic ones, but no unique treatment and precise follow up have been reported despite conducting various studies, however, a few patients have been studied in the previous researches. This study has been conducted with the aim of comparing pulse therapy with the conventional oral steroid therapy regarding its effects and side effects. 71 patients, considering their clinical and pathologic presentations, were randomly distributed in 2 groups of intravenous pulse therapy (case) [group 1, n=36] and the conventional oral steroid-therapy (control), [group 2, n=35]. The case group has been received 3 courses of intravenous pulse therapy following CYCLOPHOSPHAMIDE and oral steroid, where the control group was given oral steroid and AZATHIOPRINE. Clinical and laboratory conditions were similar in both groups, before the treatment. After the treatment, no significant statistically difference has been reported considering remission, recurrence and complications, but oral prednisolone intake (p<0.0001 to p=2%), hospitalization duration (p<0.0001) and weight gain (p<0.0001) were much less in the case group (pluse therapy). These findings imply that pulse therapy could be considered as an alternative for conventional oral steroid-therapy in PEMPHIGUS disease, at least when long hospitalization is not available.

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APA: Copy

SHAHIDI DADRAS, M., & SHAFIEIAN, S.. (2001). COMPARING THE EFFECT OF INTRAVENOUS PULSETHERAPY WITH CONVENTIONAL ORAL STEROID-THERAPY ON THE TREATMENT OF PATIENT WITH PEMPHIGUS, BOOALI AND LOGHMAN HAKIM HOSPITALS, TEHRAN, IRAN. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 5(4 (20)), 395-402. SID. https://sid.ir/paper/18372/en

Vancouver: Copy

SHAHIDI DADRAS M., SHAFIEIAN S.. COMPARING THE EFFECT OF INTRAVENOUS PULSETHERAPY WITH CONVENTIONAL ORAL STEROID-THERAPY ON THE TREATMENT OF PATIENT WITH PEMPHIGUS, BOOALI AND LOGHMAN HAKIM HOSPITALS, TEHRAN, IRAN. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;5(4 (20)):395-402. Available from: https://sid.ir/paper/18372/en

IEEE: Copy

M. SHAHIDI DADRAS, and S. SHAFIEIAN, “COMPARING THE EFFECT OF INTRAVENOUS PULSETHERAPY WITH CONVENTIONAL ORAL STEROID-THERAPY ON THE TREATMENT OF PATIENT WITH PEMPHIGUS, BOOALI AND LOGHMAN HAKIM HOSPITALS, TEHRAN, IRAN,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 5, no. 4 (20), pp. 395–402, 2001, [Online]. Available: https://sid.ir/paper/18372/en

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