ANTIDEPRESSANT EFFECTS ON MORPHINE ANALGESIA IN POST OPERATIVE PATIENTS

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RAFIEIAN MAHMOUD; RASTI M.

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Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:5 | Issue:4 (20) Page(s): 441-444

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Information Journal Paper

Title

ANTIDEPRESSANT EFFECTS ON MORPHINE ANALGESIA IN POST OPERATIVE PATIENTS

Author(s)

RAFIEIAN MAHMOUD | RASTI M. | Issue Writer Certificate

Keywords

ANTIDEPRESSANT DRUGSQ4

MORPHINEQ3

SURGERYQ3

Abstract

Morphine and other opioids are among the most useful drugs for pain relief, but their usage has been limited due to the side effects specially fear of tolerating and addiction. This study has been conducted with the aim of surveying the effects of amitriptyline and imipramine on MORPHINE-induced pain relief, in patients undergone abdominal operations. Meanwhile, changes of vital sign have been recorded. 270 patient undergone abdominal operations (appenditis, inguinal hernia, hydrocele, and varicocele) had entered our study. After complete consciousness, 3mg MORPHINE has been infused that repeated 8 hrs later. Placebo (group I), 10mg of amitriptyline (group 11), and 10mg of imipramine (group Ill) have administered intramuscularly along with MORPHINE. Pain score and vital sign were collected each 2 hrs for 24 hrs. Mean of pain score was reported in control group, group II and III, 2.18, 1.11, and 1.54, respectively (p<0.01). In the meanwhile, control group has shown increase in respiratory rate, pulse rate, and systolic blood pressure that were statistically significant. Changes in these parameters were not statistically significant in group II and III except of pulse rate. This could be due to relatively high pain relief in patients using antidepressants with MORPHINE. Increased pulse rate in group II may be associated with anti cholinergic effects of amitriptyline. Results have implied that using antidepressant and MORPHINE together could be helpful in pain relief and eliminates MORPHINE dosage.

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APA: Copy

RAFIEIAN, MAHMOUD, & RASTI, M.. (2001). ANTIDEPRESSANT EFFECTS ON MORPHINE ANALGESIA IN POST OPERATIVE PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 5(4 (20)), 441-444. SID. https://sid.ir/paper/18375/en

Vancouver: Copy

RAFIEIAN MAHMOUD, RASTI M.. ANTIDEPRESSANT EFFECTS ON MORPHINE ANALGESIA IN POST OPERATIVE PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;5(4 (20)):441-444. Available from: https://sid.ir/paper/18375/en

IEEE: Copy

MAHMOUD RAFIEIAN, and M. RASTI, “ANTIDEPRESSANT EFFECTS ON MORPHINE ANALGESIA IN POST OPERATIVE PATIENTS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 5, no. 4 (20), pp. 441–444, 2001, [Online]. Available: https://sid.ir/paper/18375/en

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