INCIDENCE OF UROLITHIASIS FOLLOWING CEFTRIAXONE CONSUMPTION IN PATIENTS WITH URINARY INFECTIONS AT MOFID CHILDREN HOSPITAL, 2003-2004

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MOHKAM M.; DANESHMAND H.; SHARIFIAN M.; GHOUJEHVAND N.

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:4 (46) Page(s): 257-260

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Title

INCIDENCE OF UROLITHIASIS FOLLOWING CEFTRIAXONE CONSUMPTION IN PATIENTS WITH URINARY INFECTIONS AT MOFID CHILDREN HOSPITAL, 2003-2004

Author(s)

MOHKAM M. | DANESHMAND H. | SHARIFIAN M. | GHOUJEHVAND N. | Issue Writer Certificate

Keywords

UROLITHIASISQ3

PEDIATRICQ3

CEFTRIAXONEQ3

Abstract

Background: The incidence of UROLITHIASIS is gradually increasing and it is about 109/100000/year in females and 36/100000/year in males. Prevalence of UROLITHIASIS is 1.7 - 4.1% in females and about 4 - 9% in males. Nowadays one of the most important etiologic factors for production of stones is drug. CEFTRIAXONE is a widely used third-generation cephalosporin. It is generally very safe, but complications of biliary pseudolithiasis, cholecyctitis and, rarely, nephrolithiasis have been reported in children. The aim of this study was to evaluate the prevalence of nephrolithiasis due to CEFTRIAXONE therapy in children.Materials and Methods: This is a Quasi Experimental and a before and after study conducted between act. 2003 Oct. 2004 on all children admitted due to pyelonephritis at Mofid Childrens Hospital. All patients treated with CEFTRIAXONE 75 mg/kg (max= 2 g/day) intravenousjy method. Diagnosis of pyelonephritis was based on standard criteria. First kidney ultrasonography has done at 1st and 2nd days of admission and second time at the last days of admission. We also evaluated target patients with third kidney ultrasonography three months after treatment. After detection of stone in ultrasonography blood and timed urine samples were obtained for hematological and biochemical tests to rule out other causes of nephrolithiasis.Results: We evaluated 184 PEDIATRIC patients 135 (73%) female and 49 (27%) male. The first US was normal in all of our patients. On the second evaluation the presence of one was reported in two children (1.1%). A 8-year - old girl and a 4 -month - old boy, biochemical laboratory tests and random urine for stone evaluation were in normal ranges in both children. Patients remained symptom free up to three months. Last kidney ultrasonography performed 3 months after discontinuation of treatment and the results of both ultrasonogram were normal.Conclusion: CEFTRIAXONE can cause nephrolithiasis. Dehydration and immobilization are important predisposing factors for formation of stone. This complication can be self limited as far as hydration and mobilization are maintained. So clinicians and radiologists should be aware of this complication as an etiology of nephrolithiasis. The antibacterial and pharmacokinetic benefits of CEFTRIAXONE outweigh the problem of reversible nephrolithiasis with this antibibiotic.

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APA: Copy

MOHKAM, M., DANESHMAND, H., SHARIFIAN, M., & GHOUJEHVAND, N.. (2005). INCIDENCE OF UROLITHIASIS FOLLOWING CEFTRIAXONE CONSUMPTION IN PATIENTS WITH URINARY INFECTIONS AT MOFID CHILDREN HOSPITAL, 2003-2004. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(4 (46)), 257-260. SID. https://sid.ir/paper/18468/en

Vancouver: Copy

MOHKAM M., DANESHMAND H., SHARIFIAN M., GHOUJEHVAND N.. INCIDENCE OF UROLITHIASIS FOLLOWING CEFTRIAXONE CONSUMPTION IN PATIENTS WITH URINARY INFECTIONS AT MOFID CHILDREN HOSPITAL, 2003-2004. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(4 (46)):257-260. Available from: https://sid.ir/paper/18468/en

IEEE: Copy

M. MOHKAM, H. DANESHMAND, M. SHARIFIAN, and N. GHOUJEHVAND, “INCIDENCE OF UROLITHIASIS FOLLOWING CEFTRIAXONE CONSUMPTION IN PATIENTS WITH URINARY INFECTIONS AT MOFID CHILDREN HOSPITAL, 2003-2004,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 4 (46), pp. 257–260, 2005, [Online]. Available: https://sid.ir/paper/18468/en

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