EFFECTS OF COMBINATION OF VITAMIN E AND NICOTINIC AACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TABIBI H.; SIASI F.; MAHDAVI MAZDEH M.; JALALI MAHMOUD; ESHRAGHIAN M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:12 | Issue:4 (58) Page(s): 259-272

Download Full-Text

Persian Verion

View:

1,781

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF COMBINATION OF VITAMIN E AND NICOTINIC AACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS

Author(s)

Keywords

VITAMIN EQ3

NICOTINIC ACIDQ4

HEMODIALYSISQ3

LIPIDSQ4

APOPROTEINSQ3

Abstract

Background: Oxidative stress and lipid abnormalities are two major risk factors for development of atherosclerosis among hemodialyzed patients. Administrating of Lipid-normalising agents, solely or in combination together, can not correct all lipid abnonnalities in hemodialyzed patients. The present study, therefore, was desinged to evaluate the effects of combination therapy of VITAMIN E and tolerable doses of NICOTINIC ACID on serum LIPIDS and APOPROTEINS in hypertriglyceridemic hemodialyzed patients.Materials and Methods: The study was a double-blind randomized clinical trial. Thirty-nine hemodialyzed patients with fasting triglyceride range between 230 and 500 mg/dl were randomly assigned into three groups, receiving combination of VITAMIN E (600mg/d) and NICOTINIC ACID (500mg/d), NICOTINIC ACID alone (500mg/d), and placebo, respectively. All patients received their supplements for 13 weeks. The blood samples were collected after a 12 to 14-hour duration of fasting at the beginning of the study, followed by other samplings performed at the end of sixth and thirteenth weeks, respectively, and serum LIPIDS and APOPROTEINS were measured accordingly.Results: During the study, the mean serum triglyceride level was significantly reduced in the group receiving combination therapy of VITAMIN E and NICOTINIC ACID, compared to the placebo group. Compared to that of placebo group, mean serum HDL-C levels were significantly increased two groups of combination therapy, and NICOTINIC ACID alone, although LDL-C/HDL-C ratios were significantly decreased. There was no significant difference in the means of total cholesterol of serum, LDL-C , apoAI, apoB100 and Lp(a) between three groups.Conclusion: It is concluded that combination therapy of VITAMIN E and NICOTINIC ACID in hypertriglyceridemic hemodialyzed patients can result in improvement in almost every lipid abnormalities, but except high levels of Lp(a).

Cites

No record.

References

بررسی تاثیر ویتامین E تکمیلی بر روی چربیهای خون خرگوش

Cite

APA: Copy

TABIBI, H., SIASI, F., MAHDAVI MAZDEH, M., JALALI, MAHMOUD, & ESHRAGHIAN, M.R.. (2007). EFFECTS OF COMBINATION OF VITAMIN E AND NICOTINIC AACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 12(4 (58)), 259-272. SID. https://sid.ir/paper/18548/en

Vancouver: Copy

TABIBI H., SIASI F., MAHDAVI MAZDEH M., JALALI MAHMOUD, ESHRAGHIAN M.R.. EFFECTS OF COMBINATION OF VITAMIN E AND NICOTINIC AACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;12(4 (58)):259-272. Available from: https://sid.ir/paper/18548/en

IEEE: Copy

H. TABIBI, F. SIASI, M. MAHDAVI MAZDEH, MAHMOUD JALALI, and M.R. ESHRAGHIAN, “EFFECTS OF COMBINATION OF VITAMIN E AND NICOTINIC AACID ON SERUM LIPIDS AND APOPROTEINS OF HYPERTRIGLYCERIDEMIC HEMODIALYZED PATIENTS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 12, no. 4 (58), pp. 259–272, 2007, [Online]. Available: https://sid.ir/paper/18548/en

Related Journal Papers