EVALUATION OF EXPRESSION & INTENSITY OF CYTIOKERATIN-10 AND 19 IN ODONTOGENIC KERATOCYST (OKC) WITH IMMUNOHISTOCHEMICAL STAINING AND COMPARING IT WITH DENTIGEROUS CYST & DENTAL FOLLICLE

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MOSHREF M.; SARGOLZAEI S.; MASHHADI ABBAS F.; MOJTAHEDI ABD ALAZIM

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Journal: Researcher Bulletin of Medical Sciences Year:2007 | Volume:12 | Issue:2 (56) Page(s): 115-121

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Title

EVALUATION OF EXPRESSION & INTENSITY OF CYTIOKERATIN-10 AND 19 IN ODONTOGENIC KERATOCYST (OKC) WITH IMMUNOHISTOCHEMICAL STAINING AND COMPARING IT WITH DENTIGEROUS CYST & DENTAL FOLLICLE

Author(s)

MOSHREF M. | SARGOLZAEI S. | MASHHADI ABBAS F. | MOJTAHEDI ABD ALAZIM | Issue Writer Certificate

Keywords

IMMUNOHISTOCHEMISTRYQ3

CYTOKERATINQ3

ODONTOGENIC KERATOCYST (OKC)Q3

DENTIGEROUS CYSTQ3

DENTAL FOLLICLEQ3

Abstract

Background: Odontogenic keratocyst (OKC) and DENTIGEROUS CYST are two most common developmental odontogenic cysts involving jaws. OKC has a high growth potential in contrast to its minor clinical manifestation. It has also a high degree of recurrence rate. The purpose of this study was to diagnose the OKC and DENTIGEROUS CYSTs and also differentiate them based on their immunohistochemical criteria. Materials and Methods: To provide the materials for this research, we preliminarely reviewed the records of the patients referred to pathology lab of shahid Beheshti Dental College between March 1999 and March 2003 and 60 paraffin-embedded biopsies (20 OKC, 20 DENTIGEROUS CYSTs and 20 DENTAL FOLLICLEs) were selected. Then immunhistochemical staining was applied to identify CYTOKERATIN-10 (CK-10) and CYTOKERATIN-19 (CK-19) and their conditions, as well. Results: The expression of CK-10, CK-19 is seen in OKC and DENTIGEROUS CYST. CK-10 was found more in OKC, along with CK-19 in DENTIGEROUS CYST. The expression of these CYTOKERATINs was more in upper half of the epithelial lining of these cysts. One of the DENTAL FOLLICLEs expressed CK-19, but not CK-10. Conclusion: CK-10 is more specific for OKC as well as CK-19 for DENTIGEROUS CYST. These CYTOKERATINs are usually seen in the upper layers of the cyst lining. If an expression of CYTOKERATIN-19 is found in a DENTAL FOLLICLE, it may correspond the cystic transformation of the latter one.

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APA: Copy

MOSHREF, M., SARGOLZAEI, S., MASHHADI ABBAS, F., & MOJTAHEDI, ABD ALAZIM. (2007). EVALUATION OF EXPRESSION & INTENSITY OF CYTIOKERATIN-10 AND 19 IN ODONTOGENIC KERATOCYST (OKC) WITH IMMUNOHISTOCHEMICAL STAINING AND COMPARING IT WITH DENTIGEROUS CYST & DENTAL FOLLICLE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 12(2 (56)), 115-121. SID. https://sid.ir/paper/18593/en

Vancouver: Copy

MOSHREF M., SARGOLZAEI S., MASHHADI ABBAS F., MOJTAHEDI ABD ALAZIM. EVALUATION OF EXPRESSION & INTENSITY OF CYTIOKERATIN-10 AND 19 IN ODONTOGENIC KERATOCYST (OKC) WITH IMMUNOHISTOCHEMICAL STAINING AND COMPARING IT WITH DENTIGEROUS CYST & DENTAL FOLLICLE. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2007;12(2 (56)):115-121. Available from: https://sid.ir/paper/18593/en

IEEE: Copy

M. MOSHREF, S. SARGOLZAEI, F. MASHHADI ABBAS, and ABD ALAZIM MOJTAHEDI, “EVALUATION OF EXPRESSION & INTENSITY OF CYTIOKERATIN-10 AND 19 IN ODONTOGENIC KERATOCYST (OKC) WITH IMMUNOHISTOCHEMICAL STAINING AND COMPARING IT WITH DENTIGEROUS CYST & DENTAL FOLLICLE,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 12, no. 2 (56), pp. 115–121, 2007, [Online]. Available: https://sid.ir/paper/18593/en

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