EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD

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POURSEIDI B.; BAZRAFSHANI M.R.; RASTINNIA S.; HOSSEINI F.S.

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Journal Paper

Paper Information

Journal: JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:7 | Issue:3 Page(s): 519-526

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Title

EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD

Author(s)

POURSEIDI B. | BAZRAFSHANI M.R. | RASTINNIA S. | HOSSEINI F.S. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

HER2/NEU OVEREXPRESSIONQ2

MLPAQ2

Abstract

Background & Objectives: Her2/neu is a biomarker which is overexpressed in a subset of BREAST CANCER patients who are eligible to receive treatment. Her-2 gene amplification analyzed by MLPA that is a new method to detect Her-2 status in clinical practice.Material and Methods: 60 patients, who were operated in Afzalipour Hospital of Kerman, were enrolled in this cross-sectional study. The pathologic specimens were evaluated by MLPA method for detecting HER2 overexpression. The data were analyzed by SPSS21 software and CHI SQUARE test.Results: Correlation between HER2 overexpression and lymph node involvement was remarkable (P value=0.0). HER2 over overexpression and size of tumor had obvious relation (P value=0.036). All the patients with HER2 overexpression were stage3 of malignancy (P value=0.0).Conclusion: According to the results of this study it can be concluded MLPA method is a suitable method for detecting overexpression of HER2 in patients with BREAST CANCER.

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APA: Copy

POURSEIDI, B., BAZRAFSHANI, M.R., RASTINNIA, S., & HOSSEINI, F.S.. (2015). EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 7(3), 519-526. SID. https://sid.ir/paper/187028/en

Vancouver: Copy

POURSEIDI B., BAZRAFSHANI M.R., RASTINNIA S., HOSSEINI F.S.. EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;7(3):519-526. Available from: https://sid.ir/paper/187028/en

IEEE: Copy

B. POURSEIDI, M.R. BAZRAFSHANI, S. RASTINNIA, and F.S. HOSSEINI, “EVALUATION OF HER2/NEU GENE AMPLIFICATION (DUPLICATIONS) FREQUENCY IN PATIENTS WITH BREAST CANCER USING MLPA METHOD,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 3, pp. 519–526, 2015, [Online]. Available: https://sid.ir/paper/187028/en

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