INVESTIGATING EFFECTIVE FACTORS ON INTRA CYTOPLASMIC SPERM INJECTION EMBRYO QUALITY USING THE MARGINAL AND GENERALIZED ADDITIVE STATISTICAL MODELS

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MANSOURI S.; NOURIJELYANI K.; NASR ESFAHANI M.H.; MOHAMMAD K.; ESHRAGHIAN M.R.; YASERI M.; GOHARI M.R.; TAVALAEE M.; DEEMEH M.R.

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Journal: JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:3 | Issue:BIOSTATISTICS AND EPIDEMIOLOGY SUPPLEMENT Page(s): 115-125

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Title

INVESTIGATING EFFECTIVE FACTORS ON INTRA CYTOPLASMIC SPERM INJECTION EMBRYO QUALITY USING THE MARGINAL AND GENERALIZED ADDITIVE STATISTICAL MODELS

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Keywords

GENERALIZED ADDITIVE MODELS (GAM)Q2

GENERALIZED ESTIMATING EQUATIONS (GEE)Q2

INTRA CYTOPLASMIC SPERM INJECTIONQ2

IN VITRO FERTILIZATIONQ2

Abstract

Background & Objectives: In IN VITRO FERTILIZATION techniques it is always better to transform a high quality embryo into uterus to enhance the chance of the success. Therefore, a comprehensive research was conducted to identify important factors related to the embryo quality. We considered potential correlation between embryos derived from an infertile couple. In addition, possible nonlinear relationships between the factors and the embryo quality were investigated.Materials& Methods: In this study, the statistical method of generalized additive models (GAM) has been employed to determine any nonlinear relationship between quantitative exploratory variables and the response.Then, the results were used to analyze the data using the Generalized Estimating Equation (GEE) technique.Result: Based on results of the GEE, linear relationships of drugs, type of infertility, and polycystic ovary syndrome was statistically significant on embryo quality. Interestingly, after examining the nonlinear relationships with GAM, in addition to the above variables, smoking status, sperm motility, and uterine factor were also shown to be significant.Conclusion: Since observations on a single subject in fertilization techniques are correlated and the relationship between factors and outcomes of fertilization may not be linear, the usual methods of GAM should incorporate the potential intra-cluster correlation using models such as the GEE.

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APA: Copy

MANSOURI, S., NOURIJELYANI, K., NASR ESFAHANI, M.H., MOHAMMAD, K., ESHRAGHIAN, M.R., YASERI, M., GOHARI, M.R., TAVALAEE, M., & DEEMEH, M.R.. (2011). INVESTIGATING EFFECTIVE FACTORS ON INTRA CYTOPLASMIC SPERM INJECTION EMBRYO QUALITY USING THE MARGINAL AND GENERALIZED ADDITIVE STATISTICAL MODELS. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, 3(BIOSTATISTICS AND EPIDEMIOLOGY SUPPLEMENT), 115-125. SID. https://sid.ir/paper/187071/en

Vancouver: Copy

MANSOURI S., NOURIJELYANI K., NASR ESFAHANI M.H., MOHAMMAD K., ESHRAGHIAN M.R., YASERI M., GOHARI M.R., TAVALAEE M., DEEMEH M.R.. INVESTIGATING EFFECTIVE FACTORS ON INTRA CYTOPLASMIC SPERM INJECTION EMBRYO QUALITY USING THE MARGINAL AND GENERALIZED ADDITIVE STATISTICAL MODELS. JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;3(BIOSTATISTICS AND EPIDEMIOLOGY SUPPLEMENT):115-125. Available from: https://sid.ir/paper/187071/en

IEEE: Copy

S. MANSOURI, K. NOURIJELYANI, M.H. NASR ESFAHANI, K. MOHAMMAD, M.R. ESHRAGHIAN, M. YASERI, M.R. GOHARI, M. TAVALAEE, and M.R. DEEMEH, “INVESTIGATING EFFECTIVE FACTORS ON INTRA CYTOPLASMIC SPERM INJECTION EMBRYO QUALITY USING THE MARGINAL AND GENERALIZED ADDITIVE STATISTICAL MODELS,” JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES, vol. 3, no. BIOSTATISTICS AND EPIDEMIOLOGY SUPPLEMENT, pp. 115–125, 2011, [Online]. Available: https://sid.ir/paper/187071/en

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