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Information Journal Paper

Title

EFFECT OF PENTOXIFYLLINE ON HISTOMORPHOLOGICAL CHANGES OF KIDNEY AFTER ECSTASY (MDMA) ADMINISTRATION IN MALE WISTAR RAT.

Pages

  35-43

Abstract

 Methylenedioxymethamphetamine (MDMA), the ECSTASY brand, leads to cell death in many tissues such as KIDNEY because of its oxidative stress properties. The present study aimed to investigate the possible effects of vasodilators such as PENTOXIFYLLINE as a vasodilators on ECSTASY induced renal damage caused by ECSTASY abuse. This experimental study was carried out in four groups of six male wWistar RATs weighing 250-300 g (n=24). The control group was kept under standard laboratory conditions. In ECSTASY group, this substance was injected (as 7.5 mg/kg, q 2 hX3 doses) intraperitoneally (IP) in the treatment group. In pentoxyfyllinePTX (PTX) treated group, 200 mg/kg of PENTOXIFYLLINE PTX was concurrently administered with the third dose of ECSTASY injection and in vehicle group, normal saline was injected. Animals’ The KIDNEYs were evaluated for HISTOMORPHOLOGICAL CHANGES by H&E and PAS stainings. Then the degrees of renal damage were measured scored by Image Tools Version 2 software. Although There were no significant differences in diameter and number of glomerular cells between control and pentoxifyl line PTX treated groups was detected. However, a significant difference was seen with between vehicle and ECSTASY groups (P<0.05). Tubulointerstitial injury was seen in ECSTASY and vehicle groups but it had been decreased in pentoxyfyllinePTX treated group. Findings of this study suggest that PENTOXIFYLLINE PTX can excertexert a positivesignificant effect on improving the ECSTASY induced renal tissue injury injuriescaused by ECSTASY abuse.

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    APA: Copy

    ASHOORI BARMCHI, ALIEH, SHARIFI, ZAHRA NADIA, SHAFAROODI, HAMED, HASHEMZADEH, ELHAM, & MOVASSAGHI, SHABNAM. (2014). EFFECT OF PENTOXIFYLLINE ON HISTOMORPHOLOGICAL CHANGES OF KIDNEY AFTER ECSTASY (MDMA) ADMINISTRATION IN MALE WISTAR RAT.. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 3(1), 35-43. SID. https://sid.ir/paper/188739/en

    Vancouver: Copy

    ASHOORI BARMCHI ALIEH, SHARIFI ZAHRA NADIA, SHAFAROODI HAMED, HASHEMZADEH ELHAM, MOVASSAGHI SHABNAM. EFFECT OF PENTOXIFYLLINE ON HISTOMORPHOLOGICAL CHANGES OF KIDNEY AFTER ECSTASY (MDMA) ADMINISTRATION IN MALE WISTAR RAT.. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2014;3(1):35-43. Available from: https://sid.ir/paper/188739/en

    IEEE: Copy

    ALIEH ASHOORI BARMCHI, ZAHRA NADIA SHARIFI, HAMED SHAFAROODI, ELHAM HASHEMZADEH, and SHABNAM MOVASSAGHI, “EFFECT OF PENTOXIFYLLINE ON HISTOMORPHOLOGICAL CHANGES OF KIDNEY AFTER ECSTASY (MDMA) ADMINISTRATION IN MALE WISTAR RAT.,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 3, no. 1, pp. 35–43, 2014, [Online]. Available: https://sid.ir/paper/188739/en

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