SILVER NANOPARTICLE INDUCED MUSCLE ABNORMALITIES: A SUB-CHRONIC DERMAL ASSESSMENT IN GUINEA PIG

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KORANI MITRA; REZAYAT SEYED MEHDI; GHAMAMI SEYEDEH GITI

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:1 | Issue:3 Page(s): 143-151

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Title

SILVER NANOPARTICLE INDUCED MUSCLE ABNORMALITIES: A SUB-CHRONIC DERMAL ASSESSMENT IN GUINEA PIG

Author(s)

KORANI MITRA | REZAYAT SEYED MEHDI | GHAMAMI SEYEDEH GITI | Issue Writer Certificate

Keywords

NANOSILVERQ1

HISTOPATHOLOGICAL CHANGESQ1

SUB-CHRONIC TOXICITYQ1

DERMAL TOXICITYQ1

Abstract

NANOSILVER has recently been recognized as an antimicrobial agent. Although this nanoparticle can be used in medical applications but its dermal and systemic toxicity via dermal exposure has not been completely determined yet. The aim in this study was to investigate the potential DERMAL TOXICITY of NANOSILVER in subchronic method. Before the colloidal silver nanoparticle toxicity evaluation, their size was subjected in sizes<100 nm by Transmission Electron Microscope and revealed that the nanoparticles contained NANOSILVER by X-Ray Diffraction. The selected animals were 24 male guinea pigs weighing 350-400 g. These animals were exposed to three concentrations of NANOSILVER (100, 1000 and 10000 mg/ml) by dermal exposure. Toxic responses were assessed based on histopathologic parameters. Significant dose-dependent HISTOPATHOLOGICAL CHANGES were observed in the muscle of treated animals. It seems that colloidal silver nanoparticles have the ability to create dose-dependent toxic responses in this organ.

Cites

EVALUATION OF DERMAL ABSORPTION OF NANOSILVER PARTICLES ON THE RENAL FUNCTION PARAMETERS IN MALE MICE

References

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APA: Copy

KORANI, MITRA, REZAYAT, SEYED MEHDI, & GHAMAMI, SEYEDEH GITI. (2013). SILVER NANOPARTICLE INDUCED MUSCLE ABNORMALITIES: A SUB-CHRONIC DERMAL ASSESSMENT IN GUINEA PIG. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 1(3), 143-151. SID. https://sid.ir/paper/188756/en

Vancouver: Copy

KORANI MITRA, REZAYAT SEYED MEHDI, GHAMAMI SEYEDEH GITI. SILVER NANOPARTICLE INDUCED MUSCLE ABNORMALITIES: A SUB-CHRONIC DERMAL ASSESSMENT IN GUINEA PIG. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;1(3):143-151. Available from: https://sid.ir/paper/188756/en

IEEE: Copy

MITRA KORANI, SEYED MEHDI REZAYAT, and SEYEDEH GITI GHAMAMI, “SILVER NANOPARTICLE INDUCED MUSCLE ABNORMALITIES: A SUB-CHRONIC DERMAL ASSESSMENT IN GUINEA PIG,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 1, no. 3, pp. 143–151, 2013, [Online]. Available: https://sid.ir/paper/188756/en

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