FORMULATION, RELEASE AND STABILITY STUDY OF BUPROPION SUSTAINED RELEASE 150 MG USING HYDROXYPROPYLMETHYLCELLULOSE (HPMC) 4000CPS BASIS

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ERFANI NAFISEH; AVADI MOHAMMAD REZA; MIR MOHAMMAD SADEGHI ASSAL; MAHBOUBI ARASH; GHORBAN DADRASS ORKIDEH

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2013 | Volume:1 | Issue:3 Page(s): 165-174

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Title

FORMULATION, RELEASE AND STABILITY STUDY OF BUPROPION SUSTAINED RELEASE 150 MG USING HYDROXYPROPYLMETHYLCELLULOSE (HPMC) 4000CPS BASIS

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Keywords

CONTROLED RELEASEQ1

BUPROPIONQ2

HYDROXYPROPYLMETHYLCELLULOSEQ1

Abstract

In this study, formulation of sustained-releasingmatrix tablet of BUPROPION 150 mg, usinghydroxypropylmethylcellu lose (HPMC) 4000cps was evaluatedwith the aim of reducing the frequency of daily dose. The level of HPMC4000, polyvinylpyrolidone (PVP) and magnesium stearate (Mg St) was varied based on a 2level 3 factor factorial experimental designusing the release rate of the drug from the matrices as the response variable. Themechanism of drug release from hydrophilic matrix tablets is complicated but it is known to be related to dissolution of drug and its diffusion through the hydrated portion of matrix and erosion of the outer hydrated polymer on the matrix surface. Granules of the optimum formulations were compressed into tablets using EK-O lorsch single punch tablet machine. Evaluation of tablets including weight variation, crushing strength and friability demonstrated acceptable results. Based on dissolution data of the eight tablet formulations resulted from the experimental design, a polynomial regression equation was generated and used for obtaining the optimum formulations. Invitro dissolution tests also revealed sustained release of drug for an 8 hours period at the end of which almost complete release was achieved. According to release studies formulation A, AB and C has been selected for long term stability studies.

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APA: Copy

ERFANI, NAFISEH, AVADI, MOHAMMAD REZA, MIR MOHAMMAD SADEGHI, ASSAL, MAHBOUBI, ARASH, & GHORBAN DADRASS, ORKIDEH. (2013). FORMULATION, RELEASE AND STABILITY STUDY OF BUPROPION SUSTAINED RELEASE 150 MG USING HYDROXYPROPYLMETHYLCELLULOSE (HPMC) 4000CPS BASIS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 1(3), 165-174. SID. https://sid.ir/paper/188759/en

Vancouver: Copy

ERFANI NAFISEH, AVADI MOHAMMAD REZA, MIR MOHAMMAD SADEGHI ASSAL, MAHBOUBI ARASH, GHORBAN DADRASS ORKIDEH. FORMULATION, RELEASE AND STABILITY STUDY OF BUPROPION SUSTAINED RELEASE 150 MG USING HYDROXYPROPYLMETHYLCELLULOSE (HPMC) 4000CPS BASIS. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2013;1(3):165-174. Available from: https://sid.ir/paper/188759/en

IEEE: Copy

NAFISEH ERFANI, MOHAMMAD REZA AVADI, ASSAL MIR MOHAMMAD SADEGHI, ARASH MAHBOUBI, and ORKIDEH GHORBAN DADRASS, “FORMULATION, RELEASE AND STABILITY STUDY OF BUPROPION SUSTAINED RELEASE 150 MG USING HYDROXYPROPYLMETHYLCELLULOSE (HPMC) 4000CPS BASIS,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 1, no. 3, pp. 165–174, 2013, [Online]. Available: https://sid.ir/paper/188759/en

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