COMPARATIVE EFFECTS OF EARTHWORM EXTRACT AND PHENYTOIN SODIUM ON SUTURE WOUND HEALING IN GOLDFISH (CARASSIUS AURATUS)

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HEYDARI S.; ARABI M.; NEMATOLLAHI A.; KARIMI I.; BIGHAM SADEGH A.

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Journal: JOURNAL OF CELL & TISSUE Year:2015 | Volume:5 | Issue:4 Page(s): 361-368

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Title

COMPARATIVE EFFECTS OF EARTHWORM EXTRACT AND PHENYTOIN SODIUM ON SUTURE WOUND HEALING IN GOLDFISH (CARASSIUS AURATUS)

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Keywords

HEALING OF SUTURE WOUNDQ2

GOLDFISHQ2

EARTHWORM BODY EXTRACTQ2

PHENYTOINQ2

LPOQ3

Abstract

Aim: In this study, the extract of earthworm (Eisenia foetida) (in solvent: olive oil and vaselline) was applied as a novel healing stimulator on suture wound in GOLDFISH (Carassius auratus).Material and Methods: Groups were: negative control (Intact skin), positive control (suture wound with PHENYTOIN), pseudo-control (sham: suture wound with solvent), and experimental (suture wound with 10 mg earthworm extract). A 2 cm longitudinal cut was made from head to tail, and then suture was applied followed by daily treatments. After 14 days, blood samples were collected. Macroscopic and microscopic observations were also done. Meanwhile, the content of lipid peroxidation (LPO/MDA) was measured in fish blood sera.Results: surface and microscopic observations of wounds revealed a better result for earthworm extract treatment in suture wound healing when compared with PHENYTOIN. MDA level in GOLDFISH blood sera was lesser in earthworm extract-treated groups compared to other groups.Conclusion: Earthworm extract is a new candidate in aquatic wound healing. Some factors of the extract may enter the blood and ultimately activate the antioxidant systems leading to decrease the content of LPO in fish blood sera.

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APA: Copy

HEYDARI, S., ARABI, M., NEMATOLLAHI, A., KARIMI, I., & BIGHAM SADEGH, A.. (2015). COMPARATIVE EFFECTS OF EARTHWORM EXTRACT AND PHENYTOIN SODIUM ON SUTURE WOUND HEALING IN GOLDFISH (CARASSIUS AURATUS). JOURNAL OF CELL & TISSUE, 5(4), 361-368. SID. https://sid.ir/paper/188929/en

Vancouver: Copy

HEYDARI S., ARABI M., NEMATOLLAHI A., KARIMI I., BIGHAM SADEGH A.. COMPARATIVE EFFECTS OF EARTHWORM EXTRACT AND PHENYTOIN SODIUM ON SUTURE WOUND HEALING IN GOLDFISH (CARASSIUS AURATUS). JOURNAL OF CELL & TISSUE[Internet]. 2015;5(4):361-368. Available from: https://sid.ir/paper/188929/en

IEEE: Copy

S. HEYDARI, M. ARABI, A. NEMATOLLAHI, I. KARIMI, and A. BIGHAM SADEGH, “COMPARATIVE EFFECTS OF EARTHWORM EXTRACT AND PHENYTOIN SODIUM ON SUTURE WOUND HEALING IN GOLDFISH (CARASSIUS AURATUS),” JOURNAL OF CELL & TISSUE, vol. 5, no. 4, pp. 361–368, 2015, [Online]. Available: https://sid.ir/paper/188929/en

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