EVALUATION OF MYELIN SHEATH AND THEIR RELATED PROTEINS (MAG, MOG, MBP AND PLP) DURING CUPRIZONE-INDUCED DEMYELINATION IN CENTRAL NERVOUS SYSTEM OF MALE C57BL/6 MICE

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SANADGO N.; KOMIJANI M.

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Paper Information

Journal: JOURNAL OF CELL & TISSUE Year:2017 | Volume:8 | Issue:1 Page(s): 12-21

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Title

EVALUATION OF MYELIN SHEATH AND THEIR RELATED PROTEINS (MAG, MOG, MBP AND PLP) DURING CUPRIZONE-INDUCED DEMYELINATION IN CENTRAL NERVOUS SYSTEM OF MALE C57BL/6 MICE

Author(s)

SANADGO N. | KOMIJANI M. | Issue Writer Certificate

Keywords

CUPRIZONEQ1

CORPUS CALLOSUMQ1

MYELIN SHEATHQ1

DEMYELINATIONQ2

Abstract

Aim: The aim of this study was to investigate of CUPRIZONE time-dependent effects on MAG, MOG, MBP, and PLP proteins and DEMYELINATION process.Materials and Methods: The myelin degradation model was created with a five week diet containing 0.2% of CUPRIZONE. The rats brain CORPUS CALLOSUM region was subjected to tissue and molecular evaluation at weeks 3, 4 and 5. At the end of the fifth week, behavioral studies were performed by open field test.Results: Results showed that the expression of MYELIN SHEATH proteins decreased time-dependently in comparison with the control group. Despite the overall reduction of these proteins in the third week, only PLP protein decreased significantly in this week comparing to control (P<0.01). Other proteins also showed a significant reduction in expression after the fourth week. Electron microscopy studies showed significant changes in the reduction of myelin diameter in comparison to the control group only after 4 weeks (p<0.01). Behavioral studies also indicated that CUPRIZONE was able to cause significant behavioral abnormalities in the animals from the beginning of the third week compared to the control group.Conclusion: This research was the first time to study the main myelin proteins at the same time, and the results show that the best time for accurate molecular, tissue and behavioral reviews are fourth and fifth weeks.

Cites

Effect of swimming on oligodendrocytic cells and myelin tissue in corpus callosum of rat model of MS induced by Cuprizone

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APA: Copy

SANADGO, N., & KOMIJANI, M.. (2017). EVALUATION OF MYELIN SHEATH AND THEIR RELATED PROTEINS (MAG, MOG, MBP AND PLP) DURING CUPRIZONE-INDUCED DEMYELINATION IN CENTRAL NERVOUS SYSTEM OF MALE C57BL/6 MICE. JOURNAL OF CELL & TISSUE, 8(1 ), 12-21. SID. https://sid.ir/paper/189127/en

Vancouver: Copy

SANADGO N., KOMIJANI M.. EVALUATION OF MYELIN SHEATH AND THEIR RELATED PROTEINS (MAG, MOG, MBP AND PLP) DURING CUPRIZONE-INDUCED DEMYELINATION IN CENTRAL NERVOUS SYSTEM OF MALE C57BL/6 MICE. JOURNAL OF CELL & TISSUE[Internet]. 2017;8(1 ):12-21. Available from: https://sid.ir/paper/189127/en

IEEE: Copy

N. SANADGO, and M. KOMIJANI, “EVALUATION OF MYELIN SHEATH AND THEIR RELATED PROTEINS (MAG, MOG, MBP AND PLP) DURING CUPRIZONE-INDUCED DEMYELINATION IN CENTRAL NERVOUS SYSTEM OF MALE C57BL/6 MICE,” JOURNAL OF CELL & TISSUE, vol. 8, no. 1 , pp. 12–21, 2017, [Online]. Available: https://sid.ir/paper/189127/en

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