STUDY OF THE HEPATOPROTECTIVE EFFECT OF CAPPARIS SPINOSA FRUIT EXTRACT AGAINST ACETAMINOPHEN-INDUCED TOXICITY IN RAT

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ESLAMI M.; FARROKHI F.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2015 | Volume:8 | Issue:1 (28) Page(s): 55-62

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Title

STUDY OF THE HEPATOPROTECTIVE EFFECT OF CAPPARIS SPINOSA FRUIT EXTRACT AGAINST ACETAMINOPHEN-INDUCED TOXICITY IN RAT

Author(s)

ESLAMI M. | FARROKHI F. | Issue Writer Certificate

Keywords

ACETAMINOPHENQ2

CAPPARIS SPINOSAQ2

HEPATOTOXICITYQ2

Abstract

Introduction & Objective: ACETAMINOPHEN (paracetamol, APAP) is a widely used analgesic and antipyretic drug. At the therapeutic doses, APAP is considered a safe drug. However, its toxic doses can lead to liver damage and is often fatal. The HEPATOTOXICITY of APAP is mainly a result of oxidative stress mediated by the metabolite of APAP, that is, N-acetyl-para-benzoquinon imine (NAPQI). The present study was undertaken to evaluate protective activity of the aqueous extract of CAPPARIS SPINOSA (Capparidaceae) fruit against APAP-induced HEPATOTOXICITY in rats.Material & Methods: In this study, animals randomly were divided into five groups (6 rats in each group). The safe and APAP-intoxicated control groups were received normal saline and the remaining groups received aqueous extract with different doses 50, 100 and 200 mg/kg by gavage. For induction of HEPATOTOXICITY, in the end of the treatment, APAP (500 mg/kg, orally) were given animals except safe control group.Results: The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin significantly decreased in the groups received the extract when were compared to APAP-intoxicated control (P<0.05). In addition, histopathology of liver showed that the extract has reduced the HEPATOTOXICITY induced by APAP.Conclusion: These findings suggest that C. spinosa fruit extract can prevent APAP-induced HEPATOTOXICITY in rats and this is likely mediated through its antioxidant properties.

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APA: Copy

ESLAMI, M., & FARROKHI, F.. (2015). STUDY OF THE HEPATOPROTECTIVE EFFECT OF CAPPARIS SPINOSA FRUIT EXTRACT AGAINST ACETAMINOPHEN-INDUCED TOXICITY IN RAT. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 8(1 (28)), 55-62. SID. https://sid.ir/paper/191796/en

Vancouver: Copy

ESLAMI M., FARROKHI F.. STUDY OF THE HEPATOPROTECTIVE EFFECT OF CAPPARIS SPINOSA FRUIT EXTRACT AGAINST ACETAMINOPHEN-INDUCED TOXICITY IN RAT. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2015;8(1 (28)):55-62. Available from: https://sid.ir/paper/191796/en

IEEE: Copy

M. ESLAMI, and F. FARROKHI, “STUDY OF THE HEPATOPROTECTIVE EFFECT OF CAPPARIS SPINOSA FRUIT EXTRACT AGAINST ACETAMINOPHEN-INDUCED TOXICITY IN RAT,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 8, no. 1 (28), pp. 55–62, 2015, [Online]. Available: https://sid.ir/paper/191796/en

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