AMINO ACID SEQUENCE ANALYSIS OF CLEAVAGE SITE OF HEMAGGLUTININ PROTEIN IN THREE AVIAN INFLUENZA VIRUSES (H9N2)

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TOROUGHI R.; MOMAYEZ R.; POURBAKHSH S.A.

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Journal: Year:2003 | Volume:16 | Issue:(60 IN ANIMAL AND FISHERIES SCIENCES) Page(s): 95-102

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Title

AMINO ACID SEQUENCE ANALYSIS OF CLEAVAGE SITE OF HEMAGGLUTININ PROTEIN IN THREE AVIAN INFLUENZA VIRUSES (H9N2)

Author(s)

TOROUGHI R. | MOMAYEZ R. | POURBAKHSH S.A. | Issue Writer Certificate

Keywords

AVIAN INFLUENZA VIRUSQ4

HEMAGGLUTININ PROTEINQ4

H9N2Q4

PHYLOGENETIC ANALYSISQ4

Abstract

Since 1998, Iranian poultry industry has been affected by avian influenza (AI) virus, subtype H9N2. The association of high mortality with these outbreaks in the field raised the specter of a possible new genetic modified AI virus. In this study, three AI viruses (H9N2) isolated from the broiler flocks with different mortality rates were characterized. The 486 bp PCR products containing the cleavage site of hemagglutinin (HA) protein were generated and sequenced to determine molecular characterization of the isolates. Sequence analysis of main region of HAl gene of three isolates showed that the viruses had similar sequences at the cleavage site. However, none of the isolates were identical at the nucleotide as well as amino acid levels. Phylogenefic analysis of 453 bp nucleotide region of the PCR products revealed that Iranian AI viruses had very close relationship to each other indicating these came from the common source. Moreover, the maximum genetic similarity of these viruses was observed with AI viruses from Saudi Arabia, Germany and Pakistan, respectively. Overall, the results indicate that with the exception of some Chinese isolates the current status of Irantan AI viruses resembles to other Eurasian H9N2 viruses and in spite of different nucleotide sequences among the viruses there is no evidence for existence of new Al pathotype.

Cites

EXPERIMENTAL STUDY ON CO-INFECTION OF H9N2 AVIAN INFLUENZA VIRUS WITH ORNITHOBACTERIUM RHINOTRACHEALE IN SPECIFIC- PATHOGEN- FREE CHICKENS

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APA: Copy

TOROUGHI, R., MOMAYEZ, R., & POURBAKHSH, S.A.. (2003). AMINO ACID SEQUENCE ANALYSIS OF CLEAVAGE SITE OF HEMAGGLUTININ PROTEIN IN THREE AVIAN INFLUENZA VIRUSES (H9N2). PAJOUHESH-VA-SAZANDEGI, 16((60 IN ANIMAL AND FISHERIES SCIENCES)), 95-102. SID. https://sid.ir/paper/19238/en

Vancouver: Copy

TOROUGHI R., MOMAYEZ R., POURBAKHSH S.A.. AMINO ACID SEQUENCE ANALYSIS OF CLEAVAGE SITE OF HEMAGGLUTININ PROTEIN IN THREE AVIAN INFLUENZA VIRUSES (H9N2). PAJOUHESH-VA-SAZANDEGI[Internet]. 2003;16((60 IN ANIMAL AND FISHERIES SCIENCES)):95-102. Available from: https://sid.ir/paper/19238/en

IEEE: Copy

R. TOROUGHI, R. MOMAYEZ, and S.A. POURBAKHSH, “AMINO ACID SEQUENCE ANALYSIS OF CLEAVAGE SITE OF HEMAGGLUTININ PROTEIN IN THREE AVIAN INFLUENZA VIRUSES (H9N2),” PAJOUHESH-VA-SAZANDEGI, vol. 16, no. (60 IN ANIMAL AND FISHERIES SCIENCES), pp. 95–102, 2003, [Online]. Available: https://sid.ir/paper/19238/en

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