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Information Journal Paper

Title

Association of the BoLA-DRB3 alleles with peripheral blood mononuclear cell proliferation in response to Staphylococcus aureus

Pages

  369-378

Abstract

 The aim of this study was to investigate the association of bovine leukocyte antigen-DRB3 alleles with peripheral blood mononuclear cell (PBMC) proliferation in response to Staphylococcus aureus. The animals included in this study (n=347) were approximately of same age and comprised of F2 Holstein-Friesian  Charolais (n = 155), Holstein-Friesian backcross (F0 Holstein-Friesian dams crossed with unrelated F1 sires, n = 60), Charolais backcross (F1 dams crossed with F0 Charolais sire, n=46) and pure Holstein-Friesian (n = 86). A sequence-based typing method was used in order to determine the genotype of the animals at BoLA-DRB3 locus and a linear mixed model was used to evaluate the association of bovine leukocyte antigen-DRB3 alleles with peripheral blood mononuclear cell (PBMC) proliferation. Beside the BoLA-DRB3 alleles, fixed effects of genetic group and gender and random effect of sires were included into the statistical model. In this research, 27 alleles were found for BoLA-DRB3 gene. The results showed that alleles BoLA-DRB3*0101 and BoLA-DRB3*0902 significantly affected on the stimulation index of S. aureus– induced peripheral blood mononuclear cell proliferation (P<0. 05). The results may be useful for investigating the biological mechanism of immune response against S. aureus.

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    APA: Copy

    ATASHI, HADI, MORADI SHAHRBABAK, MOHAMMAD, MEHRABANI YEGANEH, HASSAN, MIRAEI ASHTIANI, SEYED REZA, & Rahimi Mianji, Ghodratolah. (2016). Association of the BoLA-DRB3 alleles with peripheral blood mononuclear cell proliferation in response to Staphylococcus aureus. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), 47(3 ), 369-378. SID. https://sid.ir/paper/193546/en

    Vancouver: Copy

    ATASHI HADI, MORADI SHAHRBABAK MOHAMMAD, MEHRABANI YEGANEH HASSAN, MIRAEI ASHTIANI SEYED REZA, Rahimi Mianji Ghodratolah. Association of the BoLA-DRB3 alleles with peripheral blood mononuclear cell proliferation in response to Staphylococcus aureus. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES)[Internet]. 2016;47(3 ):369-378. Available from: https://sid.ir/paper/193546/en

    IEEE: Copy

    HADI ATASHI, MOHAMMAD MORADI SHAHRBABAK, HASSAN MEHRABANI YEGANEH, SEYED REZA MIRAEI ASHTIANI, and Ghodratolah Rahimi Mianji, “Association of the BoLA-DRB3 alleles with peripheral blood mononuclear cell proliferation in response to Staphylococcus aureus,” IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), vol. 47, no. 3 , pp. 369–378, 2016, [Online]. Available: https://sid.ir/paper/193546/en

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