META-ANALYSIS OF TRANSCRIPTOMIC DATA OF MAMMARY GLAND INFECTED BY ESCHERICHIA COLI BACTERIA IN DAIRY COWS

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SHARIFI SOMAYEH; PAKDEL ABBAS; EBRAHIMI ESMAEIL

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Journal: Iranian Journal of Animal Science Year:2017 | Volume:48 | Issue:3 Page(s): 343-352

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Information Journal Paper

Title

META-ANALYSIS OF TRANSCRIPTOMIC DATA OF MAMMARY GLAND INFECTED BY ESCHERICHIA COLI BACTERIA IN DAIRY COWS

Author(s)

SHARIFI SOMAYEH | PAKDEL ABBAS | EBRAHIMI ESMAEIL | Issue Writer Certificate

Keywords

DAIRY COWSQ1

DIFFERENTIAL EXPRESS GENEQ1

ESCHERICHIA COLIQ1

GENE ONTOLOGYQ2

MASTITISQ1

Abstract

Identification of disease-causing genes that underlie complex traits such as susceptibility to disease not only can improve diagnosis and the prevention of illness, but also help breeder to select resistance animals against diseases. In the current study to aim the higher power of statistical analysis to identification of genes and biological pathways related to MASTITIS disease, we used Fisher meta-analysis to combinep-value s obtained from individual analysis of datasets extracted from 6 microarray-based studies which investigate transcriptomic data of mammary gland tissue infected by ESCHERICHIA COLI (E. coli) in DAIRY COWS. Identification of genes that did not show a significant p-value in any of the independent studies may confirm the aim and lead to introduce a more complete set of biological pathways involved in this disease such as the pathways related to immune response, inflammation, proteolysis, growth, and death of cell.Positive regulation of transcription from RNA polymerase II promoter, is new pathways related to this disease which despite of the enrichment by maximum number of up-regulated genes in this study, have not been reported in previous MASTITIS studies.

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APA: Copy

SHARIFI, SOMAYEH, PAKDEL, ABBAS, & EBRAHIMI, ESMAEIL. (2017). META-ANALYSIS OF TRANSCRIPTOMIC DATA OF MAMMARY GLAND INFECTED BY ESCHERICHIA COLI BACTERIA IN DAIRY COWS. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), 48(3 ), 343-352. SID. https://sid.ir/paper/193717/en

Vancouver: Copy

SHARIFI SOMAYEH, PAKDEL ABBAS, EBRAHIMI ESMAEIL. META-ANALYSIS OF TRANSCRIPTOMIC DATA OF MAMMARY GLAND INFECTED BY ESCHERICHIA COLI BACTERIA IN DAIRY COWS. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES)[Internet]. 2017;48(3 ):343-352. Available from: https://sid.ir/paper/193717/en

IEEE: Copy

SOMAYEH SHARIFI, ABBAS PAKDEL, and ESMAEIL EBRAHIMI, “META-ANALYSIS OF TRANSCRIPTOMIC DATA OF MAMMARY GLAND INFECTED BY ESCHERICHIA COLI BACTERIA IN DAIRY COWS,” IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), vol. 48, no. 3 , pp. 343–352, 2017, [Online]. Available: https://sid.ir/paper/193717/en

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