THE EFFECTS OF SPINAL ANALGESIA WITH FENTANYL ON LABOR PAIN

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BEYZAII HAMED; BABAPOUR NOUSHIN; RAEESI MOJGAN; KIAFAR MAHSA; BABAPOUR MAHSA

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Journal: JOURNAL OF MEDICAL SCIENCE OF ISLAMIC AZAD UNIVERSITY OF MASHHAD Year:2010 | Volume:6 | Issue:3 (23) Page(s): 187-194

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Title

THE EFFECTS OF SPINAL ANALGESIA WITH FENTANYL ON LABOR PAIN

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Keywords

FENTANYLQ3

SPINAL ANALGESIAQ3

PAINLESS LABORQ3

VAGINAL DELIVERYQ3

Abstract

Introduction: Labor pain is the main reason preventing pregnant women from having natural VAGINAL DELIVERY (NVD).In order to reduce the labor pain, several ways have been introduced, among which SPINAL ANALGESIA with FENTANYL is considered the most effective.FENTANYL is a lipophilic opioid with the degree of 75-125 times more potent than morphine.This study aims at evaluating the analgesic effects of FENTANYL on the process of NVD as well as the possible risks involved for the neonate after spinal injection in pregnant women.Materials and Methods: This is a single blinded clinical trial on 100 pregnant women having their first or second pregnancy who referred to Mashhad Islamic Azad University hospitals for NVD in 1389 HS. This study benefited from using the accessible method of sampling and considering he ethical issues as well applying the inclusion / exclusion criteria. Having informed the patients and their spouses about the analgesic methods, the researchers received the patients’ consent and divided them into two groups of “case” and “control” with 50 patients, each. The case group received 75 µg of FENTANYL with the concentration of 0.05 mg/ml added to sodium chloride and distilled water. These patients used the drug after getting into the cervical dilatation of 5 or 6 centimeters . The control group received no analgesic drug and experienced the natural process of labor and delivery. Systolic & Diastolic blood pressures, heart rate, SP02, the degree of cervical dilatation and effacement, fetal heart rate (FHR) and Apgar rate were evaluated during the intervals of 1 and 5 minutes after birth. Finally, these data were compared and analyzed with the statistical methods of T-test, Chi-square, Fisher and Man-Whitney, using SPSS.Results: There was no significant difference between the two study groups in terms of maternal systolic & diastolic blood pressure, SP02 and FHR. Shortly after the injection of FENTANYL, the patients in the case group started complaining about itching in the upper part of their abdomen and chest that automatically subsided after about 20-30 minutes. There was a statistically significant difference of the pain rate between the two groups (Pearson Chi-square=62.95, df=2, p=0.0001). Mild pain was seen in 82%, moderate pain in 16% and sever pain in 2% of the patients in the case group. On the other hand, only 4% of the patients in the control group were reported to have mild pain, 22% had moderate pain and the other 74% suffered from severe pain. Duration of labor was longer for the case group and the number of cases resulting in cesarean section was not statistically different between the two groups.Conclusion: Spinal injection of 75µg FENTANYL provides appropriate analgesia without any considerable side effects for the pregnant women who apply for NVD.

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APA: Copy

BEYZAII, HAMED, BABAPOUR, NOUSHIN, RAEESI, MOJGAN, KIAFAR, MAHSA, & BABAPOUR, MAHSA. (2010). THE EFFECTS OF SPINAL ANALGESIA WITH FENTANYL ON LABOR PAIN. JOURNAL OF MEDICAL SCIENCE OF ISLAMIC AZAD UNIVERSITY OF MASHHAD, 6(3 (23)), 187-194. SID. https://sid.ir/paper/194281/en

Vancouver: Copy

BEYZAII HAMED, BABAPOUR NOUSHIN, RAEESI MOJGAN, KIAFAR MAHSA, BABAPOUR MAHSA. THE EFFECTS OF SPINAL ANALGESIA WITH FENTANYL ON LABOR PAIN. JOURNAL OF MEDICAL SCIENCE OF ISLAMIC AZAD UNIVERSITY OF MASHHAD[Internet]. 2010;6(3 (23)):187-194. Available from: https://sid.ir/paper/194281/en

IEEE: Copy

HAMED BEYZAII, NOUSHIN BABAPOUR, MOJGAN RAEESI, MAHSA KIAFAR, and MAHSA BABAPOUR, “THE EFFECTS OF SPINAL ANALGESIA WITH FENTANYL ON LABOR PAIN,” JOURNAL OF MEDICAL SCIENCE OF ISLAMIC AZAD UNIVERSITY OF MASHHAD, vol. 6, no. 3 (23), pp. 187–194, 2010, [Online]. Available: https://sid.ir/paper/194281/en

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