RAPID DIAGNOSIS OF ACUTE KIDNEY INJURY (AKI) ASSOCIATED WITH CARDIAC SURGERY, USING THE LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) BIOMARKER

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MIRBAGHERI M.; TAGHIPOUR H.R.; FARHADI N.; MIRBAGHERI L.; NOURANI M.R.

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Journal: MEDICAL LABORATORY JOURNAL Year:2012 | Volume:6 | Issue:1 Page(s): 43-50

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Title

RAPID DIAGNOSIS OF ACUTE KIDNEY INJURY (AKI) ASSOCIATED WITH CARDIAC SURGERY, USING THE LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) BIOMARKER

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Keywords

ACUTE KIDNEY INJURYQ2

LIVER TYPE FATTY ACID BINDING PROTEINQ1

CARDIAC SURGERYQ2

Abstract

Background and objectives: CARDIAC SURGERY is often associated with ACUTE KIDNEY INJURY (AKI). Nowadays, AKI is typically diagnosed by an increase in serum creatinine, which is a delayed and unreliable biomarker. Recent studies recommended using the LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) as an early biomarker.Material and Methods: The urine samples of 18 adult patients undergoing CARDIAC SURGERY were collected in different times before (2, 4, 8, 24 hour) and after CARDIAC SURGERY for detection of L-FABP by Elisa.Results: The results from ELISA test show that the increasing amount of LFABP in urine samples of 4 patients is a diagnostic indicator for AKI. The mean concentration of L-FABP has increased up to 17 times at 8 hours after CARDIAC SURGERY compared to before surgery.Conclusion: according to our findings, we speculated that the urinary L-FABP can be a reliable and rapid biomarker for diagnosis of ACUTE KIDNEY INJURY.

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APA: Copy

MIRBAGHERI, M., TAGHIPOUR, H.R., FARHADI, N., MIRBAGHERI, L., & NOURANI, M.R.. (2012). RAPID DIAGNOSIS OF ACUTE KIDNEY INJURY (AKI) ASSOCIATED WITH CARDIAC SURGERY, USING THE LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) BIOMARKER. MEDICAL LABORATORY JOURNAL, 6(1), 43-50. SID. https://sid.ir/paper/194781/en

Vancouver: Copy

MIRBAGHERI M., TAGHIPOUR H.R., FARHADI N., MIRBAGHERI L., NOURANI M.R.. RAPID DIAGNOSIS OF ACUTE KIDNEY INJURY (AKI) ASSOCIATED WITH CARDIAC SURGERY, USING THE LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) BIOMARKER. MEDICAL LABORATORY JOURNAL[Internet]. 2012;6(1):43-50. Available from: https://sid.ir/paper/194781/en

IEEE: Copy

M. MIRBAGHERI, H.R. TAGHIPOUR, N. FARHADI, L. MIRBAGHERI, and M.R. NOURANI, “RAPID DIAGNOSIS OF ACUTE KIDNEY INJURY (AKI) ASSOCIATED WITH CARDIAC SURGERY, USING THE LIVER TYPE FATTY ACID BINDING PROTEIN (L-FABP) BIOMARKER,” MEDICAL LABORATORY JOURNAL, vol. 6, no. 1, pp. 43–50, 2012, [Online]. Available: https://sid.ir/paper/194781/en

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