THE INVESTIGATION OF MICROBIAL CONTAMINATION OF SEMISOLID GALEN'S DRUG IN KERMAN PHARMACIES

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ABD ELAHI A.; ZANDI F.; ZANDI S.; JAFARIAN AMIR HOSSEIN; BAHRAMPOOR A.

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Journal: Journal of Kerman University of Medical Sciences Year:2002 | Volume:9 | Issue:3 Page(s): 153-158

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Title

THE INVESTIGATION OF MICROBIAL CONTAMINATION OF SEMISOLID GALEN'S DRUG IN KERMAN PHARMACIES

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Keywords

MICROBIAL CONTAMINATIONQ3

GALEN'S DRUGQ3

FORMULATIONSQ2

PHARMACYQ3

KERMANQ3

Abstract

Any pharmaceutical product, whether manufactured in the PHARMACY, hospital or industrial environment, has the potential to be contaminated with microorgnisms. MICROBIAL CONTAMINATION may originate from the raw materials or may be introduced during manufacturing. Thus different specifications of various precision and severity have been developed, based on the potential risk posed by sterile and non-sterile categories of pharmaceutical preparations and the type of raw materials used. There is no single mandatory standard analogous to the criterion of sterility for non-sterile oral and topical FORMULATIONS and their constituent materials. However the degree of pharmaceutical safety needs to reflect the absence of microbial flora capable of eliciting biodegradation and medication-cased infection. The rational of guidelines and criteria which are based on established and potential risks from contaminated materials unfortunately varies in different countries. In this study, the microbial quality of 5 different semi-solid FORMULATIONS (10 samples of each) from 10 pharmacies operating in KERMAN, were investigated according to the United States pharmacopeia method. Forty eight FORMULATIONS (96%) had bacterial contaminations of which 86% were contaminated with more than 100 bacteria per gram. 24 samples (46%) were contaminated with gram positive bacilli, 10 samples (20%) with Staphylococcus aureus, 9 samples (18%) with Eschenchia coli, 5 samples (15%) with Pseudomonos aeruginosa, 7 samples (14%) with coagulase-negative Staphylococcus, and 7 samples (14%) with other garm positive cocci. Although the source of contamination was not investigated in this study, but it seems that most of the contaminations arising during storage of ingredients or preparation of FORMULATIONS in pharmacies. Thus it is suggested that pharmacies in KERMAN and other cities with similar problems should observe the guide-lines of manufacturing GALEN'S DRUGs to decrease the MICROBIAL CONTAMINATION for a safer usage.

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APA: Copy

ABD ELAHI, A., ZANDI, F., ZANDI, S., JAFARIAN, AMIR HOSSEIN, & BAHRAMPOOR, A.. (2002). THE INVESTIGATION OF MICROBIAL CONTAMINATION OF SEMISOLID GALEN'S DRUG IN KERMAN PHARMACIES. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 9(3), 153-158. SID. https://sid.ir/paper/195/en

Vancouver: Copy

ABD ELAHI A., ZANDI F., ZANDI S., JAFARIAN AMIR HOSSEIN, BAHRAMPOOR A.. THE INVESTIGATION OF MICROBIAL CONTAMINATION OF SEMISOLID GALEN'S DRUG IN KERMAN PHARMACIES. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(3):153-158. Available from: https://sid.ir/paper/195/en

IEEE: Copy

A. ABD ELAHI, F. ZANDI, S. ZANDI, AMIR HOSSEIN JAFARIAN, and A. BAHRAMPOOR, “THE INVESTIGATION OF MICROBIAL CONTAMINATION OF SEMISOLID GALEN'S DRUG IN KERMAN PHARMACIES,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 3, pp. 153–158, 2002, [Online]. Available: https://sid.ir/paper/195/en

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