A SURVEY ON THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF BLADDER AND ITS RELATION WITH HISTOLOGICAL GRADING

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TORABINEZHAD S.; SOHRABI Z.

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Journal: Journal of Kerman University of Medical Sciences Year:2002 | Volume:9 | Issue:3 Page(s): 114-151

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Title

A SURVEY ON THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF BLADDER AND ITS RELATION WITH HISTOLOGICAL GRADING

Author(s)

TORABINEZHAD S. | SOHRABI Z. | Issue Writer Certificate

Keywords

TRANSITIONAL CELL CARCINOMAQ4

BLADDERQ3

GRADINGQ3

DNA CONTENTQ4

Abstract

TRANSITIONAL CELL CARCINOMA (T.C.C) of BLADDER displays an unpredictable biological behavior. Morphqlogic methods of GRADING this tumor are insufficient to predict the clinical outcome of the patients. The aim of this study was to investigate the relationships between histological GRADING, staging and DNA ploidy especially in intermediate grade II (IIa and IIb). In a retrospective study of tissue specimen in 30 patients with T. C. C of the BLADDER, we compared the results of histological GRADING, staging and other morphological criteria such as vascular, lymphatic and perineural invasion with DNA ploidy. DNA CONTENT was measured by flow cytometry. There was a good correlation between histological GRADING and DNA ploidy (P<0.003). Regarding Tee grade II (a, b). There was also a good relationship between morphologic criteria and DNA CONTENT (P<0.003). There was also a positive correlation between histopathologic staging and DNA CONTENT except in one case (P<0.003). We found a significant correlation between results of DNA cytometry and vascular, lymphaticandperineural invasion (P<0.0008). Flow cytometric determination of DNA CONTENT as a complementary method is valuable in predicting prognosis of Tee especially in grade II. The exact use of morphologic criteria for GRADING of Tee can be substituted for DNA CONTENT in the absence of flow cytometry for prediction of aggressive behavior in TCC.

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APA: Copy

TORABINEZHAD, S., & SOHRABI, Z.. (2002). A SURVEY ON THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF BLADDER AND ITS RELATION WITH HISTOLOGICAL GRADING. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 9(3), 114-151. SID. https://sid.ir/paper/196/en

Vancouver: Copy

TORABINEZHAD S., SOHRABI Z.. A SURVEY ON THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF BLADDER AND ITS RELATION WITH HISTOLOGICAL GRADING. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(3):114-151. Available from: https://sid.ir/paper/196/en

IEEE: Copy

S. TORABINEZHAD, and Z. SOHRABI, “A SURVEY ON THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF BLADDER AND ITS RELATION WITH HISTOLOGICAL GRADING,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 3, pp. 114–151, 2002, [Online]. Available: https://sid.ir/paper/196/en

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