GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE

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ISSABEAGLOO E.; ZADIEH M.T.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2012 | Volume:8 (NEW) | Issue:4 (35) Page(s): 685-689

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Title

GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE

Author(s)

ISSABEAGLOO E. | ZADIEH M.T. | Issue Writer Certificate

Keywords

L. HYSSOPIFOLIAQ2

DIARRHOEAQ2

CASTER OILQ2

5-HTQ2

MICEQ2

Abstract

Diarrhoea is one of the most important GI tract that reduces meaningful performance of the patient. Dried whole plant parts of Ludwigia hyssopifolia were subjected to successive cold extraction with n-hexane, ethylacetate and methanol. The methanol extract (LHM), obtained as 1% yield, showed significant antidiarrheal property by reducing diarrheal episodes in castor oil and serotonin induced diarrhea in laboratory MICE at a dose of higher than 100mg/kg body weight as compared to standard drug loperamide given at a dose of 66.67 mg/kg body weight. The percent reduction in diarrheal episode by 56.32 and 89.66 after castor oil challenge and 59.09 and 86.36 in serotonin induced diarrhea was observed at doses of 200mg/kg and 400mg/kg body weight of the extract respectively. The extract LHM was also found to reduce the gastrointestinal motility by 53.8% at a dose of 100mg/kg body weight as compared to control, while no remarkable inhibition of gastrointestinal motility was seen at a dose of 50mg/kg body weight of the extract.

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APA: Copy

ISSABEAGLOO, E., & ZADIEH, M.T.. (2012). GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 8 (NEW)(4 (35)), 685-689. SID. https://sid.ir/paper/197259/en

Vancouver: Copy

ISSABEAGLOO E., ZADIEH M.T.. GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2012;8 (NEW)(4 (35)):685-689. Available from: https://sid.ir/paper/197259/en

IEEE: Copy

E. ISSABEAGLOO, and M.T. ZADIEH, “GASTROINTESTINAL MOTILITY ABLATIVE EFFECT OF METHANOL EXTRACT OF L. HYSSOPIFOLIA IN DIARRHOEA DUE TO CASTER OIL AND 5-HT IN MICE,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 8 (NEW), no. 4 (35), pp. 685–689, 2012, [Online]. Available: https://sid.ir/paper/197259/en

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