THE EFFECT OF THE DIFFERENT CONCENTRATIONS OF AQUEOUS EXTRACTS OF ORIGANUM VULGARIS IN SUBACUTE DAMAGE OF OXIDATIVE STRESS CAUSED BY CADMIUM IN KIDNEY OF RAT

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RAEESZADEH M.; MORTAZAVI P.; KHADEMI N.; FALAH M.M.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2017 | Volume:14 (NEW) | Issue:3 (58) Page(s): 2257-2266

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Title

THE EFFECT OF THE DIFFERENT CONCENTRATIONS OF AQUEOUS EXTRACTS OF ORIGANUM VULGARIS IN SUBACUTE DAMAGE OF OXIDATIVE STRESS CAUSED BY CADMIUM IN KIDNEY OF RAT

Author(s)

RAEESZADEH M. | MORTAZAVI P. | KHADEMI N. | FALAH M.M. | Issue Writer Certificate

Keywords

KIDNEY DAMAGEQ1

OXIDATIVE STRESSQ2

CADMIUMQ2

AQUEOUS EXTRACT OF MARJORAMQ1

RATQ2

Abstract

Due to KIDNEY DAMAGE CADMIUM, this study was an attempt to investigate the protective effect of aqueous extracts of marjoram CADMIUM in kidney.30 male Wistar RATs divided into 5 equal groups randomly: control and treatment groups 1 to 4 (T1-T4), respectively. T1 group was administrated at 2 mg/kg CADMIUM chloride intraperitoneal and T2, T3 and T4 groups in addition to CADMIUM AQUEOUS EXTRACT OF MARJORAM at a dose of 125, 250, 500 mg/kg, respectively.On the last day, the animals were weighed and blood samples for serum preparation were isolated. So that the animals were euthanized with overdose of thiopental. The right kidney was used to measure malondialdehyde and the left one was fixed in formalin-buffer 10% to pathologic studies. The results showed that the T1 group had the lowest average body weight.The different weight between the T1 group and control, 250 and 500 mg/kg of extract was significant. The MDA difference between T1 Group, T4, and control group was significant (P=0.041). The TCA concentration in T4 group was the highest of 1198.91 ± 51.45 and in T1 was the lowest average 796.41 ± 40.76 mmol/ml and the difference was significant (P=0.036).The pathological damage was graded with the degeneration of tubules of kidney, necrosis and accumulation of inflammatory cells. The high to low scoring damage was found in Group T1, T2, T3, C and T4 respectively. According to the findings, 500 mg/kg of O. vulgaris extract can prevent KIDNEY DAMAGE caused by CADMIUM chloride in RATs.

Cites

The study of the effect of hydroalcholic extracts of broccoli on lead induced oxidative stress in kidney of mice

References

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APA: Copy

RAEESZADEH, M., MORTAZAVI, P., KHADEMI, N., & FALAH, M.M.. (2017). THE EFFECT OF THE DIFFERENT CONCENTRATIONS OF AQUEOUS EXTRACTS OF ORIGANUM VULGARIS IN SUBACUTE DAMAGE OF OXIDATIVE STRESS CAUSED BY CADMIUM IN KIDNEY OF RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 14 (NEW)(3 (58)), 2257-2266. SID. https://sid.ir/paper/197308/en

Vancouver: Copy

RAEESZADEH M., MORTAZAVI P., KHADEMI N., FALAH M.M.. THE EFFECT OF THE DIFFERENT CONCENTRATIONS OF AQUEOUS EXTRACTS OF ORIGANUM VULGARIS IN SUBACUTE DAMAGE OF OXIDATIVE STRESS CAUSED BY CADMIUM IN KIDNEY OF RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2017;14 (NEW)(3 (58)):2257-2266. Available from: https://sid.ir/paper/197308/en

IEEE: Copy

M. RAEESZADEH, P. MORTAZAVI, N. KHADEMI, and M.M. FALAH, “THE EFFECT OF THE DIFFERENT CONCENTRATIONS OF AQUEOUS EXTRACTS OF ORIGANUM VULGARIS IN SUBACUTE DAMAGE OF OXIDATIVE STRESS CAUSED BY CADMIUM IN KIDNEY OF RAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 14 (NEW), no. 3 (58), pp. 2257–2266, 2017, [Online]. Available: https://sid.ir/paper/197308/en

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