COMPARATIVE EFFECT OF DEXAMETHASONE, METOCLOPRAMIDE AND COMBINATION OF DEXAMETHASONE-METOCLOPRAMIDE ADMINISTRATIONS ON POSTOPERATIVE NAUSEA AND VOMITING PROPHYLAXIS IN DOG MODEL

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MARJANI M.; KAZEMI A.; HASHEMPOUR A.R.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2015 | Volume:11 (NEW) | Issue:4 (47) Page(s): 1491-1494

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Title

COMPARATIVE EFFECT OF DEXAMETHASONE, METOCLOPRAMIDE AND COMBINATION OF DEXAMETHASONE-METOCLOPRAMIDE ADMINISTRATIONS ON POSTOPERATIVE NAUSEA AND VOMITING PROPHYLAXIS IN DOG MODEL

Author(s)

MARJANI M. | KAZEMI A. | HASHEMPOUR A.R. | Issue Writer Certificate

Keywords

VOMITINGQ3

DEXAMETHASONEQ3

METOCLOPRAMIDEQ2

XYLAZINEQ3

Abstract

Xylazine is preanesthetic drug that have nausea and VOMITING effects. This study was done in order to assessment of the effects of DEXAMETHASONE, METOCLOPRAMIDE and the combination of DEXAMETHASONE - METOCLOPRAMIDE administrations in prophylaxis of nausea and VOMITING after XYLAZINE administration in dogs.15 mixed breed dogs with average weight 18.9±5 Kg were randomly selected in 3 groups including intravenous (I.V) DEXAMETHASONE 1mg/kg, I.V METOCLOPRAMIDE 0.5 mg/kg and combination of DEXAMETHASONE - METOCLOPRAMIDE (0.5 -1 mg/kg). For induction of anesthesia in all groups, initially I.V diazepam (0.2 mg/kg) then I.V XYLAZINE (2 mg/kg) and I.V morphine (2 mg/kg) were administrated and DEXAMETHASONE, METOCLOPRAMIDE and combination of DEXAMETHASONE-metoclopramide were injected and dogs were underwent the laparotomy technique. Anesthetic and recovery times, also nausea and VOMITING effects at 30 min, 2, 4, 8 and 24 h after anesthesia were recorded and results were analyzed by ANOVA and (P<0.05) were considered significant.Duration of anesthesia at DEXAMETHASONE group were 48.2±2.8 min, METOCLOPRAMIDE group 51.7±2.3 min and in DEXAMETHASONE-metoclopramide group 45.7±2.3 min, respectively. Significant difference was not seen at duration of anesthesia between three groups (P>0.05) none was seen nausea and VOMITING. Single or co-administration of DEXAMETHASONE and METOCLOPRAMIDE prevents nausea and VOMITING in operation and recovery period.

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APA: Copy

MARJANI, M., KAZEMI, A., & HASHEMPOUR, A.R.. (2015). COMPARATIVE EFFECT OF DEXAMETHASONE, METOCLOPRAMIDE AND COMBINATION OF DEXAMETHASONE-METOCLOPRAMIDE ADMINISTRATIONS ON POSTOPERATIVE NAUSEA AND VOMITING PROPHYLAXIS IN DOG MODEL. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 11 (NEW)(4 (47)), 1491-1494. SID. https://sid.ir/paper/197356/en

Vancouver: Copy

MARJANI M., KAZEMI A., HASHEMPOUR A.R.. COMPARATIVE EFFECT OF DEXAMETHASONE, METOCLOPRAMIDE AND COMBINATION OF DEXAMETHASONE-METOCLOPRAMIDE ADMINISTRATIONS ON POSTOPERATIVE NAUSEA AND VOMITING PROPHYLAXIS IN DOG MODEL. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2015;11 (NEW)(4 (47)):1491-1494. Available from: https://sid.ir/paper/197356/en

IEEE: Copy

M. MARJANI, A. KAZEMI, and A.R. HASHEMPOUR, “COMPARATIVE EFFECT OF DEXAMETHASONE, METOCLOPRAMIDE AND COMBINATION OF DEXAMETHASONE-METOCLOPRAMIDE ADMINISTRATIONS ON POSTOPERATIVE NAUSEA AND VOMITING PROPHYLAXIS IN DOG MODEL,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 11 (NEW), no. 4 (47), pp. 1491–1494, 2015, [Online]. Available: https://sid.ir/paper/197356/en

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