PREVENTIVE EFFECTS OF EDIBLE TURMERIC POWDER (CURCUMA LONGA LINN.) ON HEPATIC STEATOSIS IN THE RATS FED WITH HIGH FAT DIET

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KAFFASHI ELAHI R.

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Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2013 | Volume:10 (NEW) | Issue:1 (40) Page(s): 889-897

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Title

PREVENTIVE EFFECTS OF EDIBLE TURMERIC POWDER (CURCUMA LONGA LINN.) ON HEPATIC STEATOSIS IN THE RATS FED WITH HIGH FAT DIET

Author(s)

KAFFASHI ELAHI R. | Issue Writer Certificate

Keywords

HIGH FAT FED DIETQ2

TURMERIC (CURCUMA LONGA LINN.)Q1

HEPATIC STEATOSISQ2

Abstract

The aim of the present study was to evaluate the preventive effects of Turmeric (Curcuma Longa Linn.) powder on rat high fat diet-induced HEPATIC STEATOSIS model. For this purpose, male wistar rats were treated in 4 experimental groups including: 1- healthy control group given standard diet, 2- high fat diet group for induction of HEPATIC STEATOSIS, 3- high fat diet plus Clofibrate (320 mg/kg) as positive control, and 4- high fat diet plus Turmeric powder (5%) for protection of liver steatosis, at a period of 6 weeks. At the end of experiment, the groups were compared considering serum lipid profile, serum biomarkers of liver tissue injury and liver histopathological changes.After 6 weeks treatment, high fat diet caused significant (p<0.001) increase in serum levels of triglyceride and cholesterol. In HIGH FAT FED DIET group, serum levels of hepatocellular enzymes and total bilirubin significantly (p<0.01) increased and serum total protein and albumin significantly (p<0.01) decreased. Turmeric treatment significantly (p<0.01) reduced elevated markers of liver tissue injury and total bilirubin and significantly (p<0.01) increased, amounts of reduced serum total protein and albumin. In addition, over accumulation of lipids in serum significantly (p<0.01) decreased towards normal. Histopathology of the liver confirmed the changes induced by high fat diet and the hepatoprotective effect of Turmeric powder. The results obtained showed that turmeric powder possesses preventive activities against HEPATIC STEATOSIS in rats fed with high fat diet.

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APA: Copy

KAFFASHI ELAHI, R.. (2013). PREVENTIVE EFFECTS OF EDIBLE TURMERIC POWDER (CURCUMA LONGA LINN.) ON HEPATIC STEATOSIS IN THE RATS FED WITH HIGH FAT DIET. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 10 (NEW)(1 (40)), 889-897. SID. https://sid.ir/paper/197408/en

Vancouver: Copy

KAFFASHI ELAHI R.. PREVENTIVE EFFECTS OF EDIBLE TURMERIC POWDER (CURCUMA LONGA LINN.) ON HEPATIC STEATOSIS IN THE RATS FED WITH HIGH FAT DIET. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2013;10 (NEW)(1 (40)):889-897. Available from: https://sid.ir/paper/197408/en

IEEE: Copy

R. KAFFASHI ELAHI, “PREVENTIVE EFFECTS OF EDIBLE TURMERIC POWDER (CURCUMA LONGA LINN.) ON HEPATIC STEATOSIS IN THE RATS FED WITH HIGH FAT DIET,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 10 (NEW), no. 1 (40), pp. 889–897, 2013, [Online]. Available: https://sid.ir/paper/197408/en

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