STUDY ON CULTIVATION OF S15 VACCINE STRAIN CELL LINE IN AEROBIC BIOREACTOR FED-BATCH SYSTEM

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HABIBI GH.; ESMAEIL NIA K.; IZADI H.; BOZORGI S.

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Paper Information

Journal: Veterinary Research & Biological Products Year:2015 | Volume:28 | Issue:2(107) Page(s): 60-66

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Title

STUDY ON CULTIVATION OF S15 VACCINE STRAIN CELL LINE IN AEROBIC BIOREACTOR FED-BATCH SYSTEM

Author(s)

HABIBI GH. | ESMAEIL NIA K. | IZADI H. | BOZORGI S. | Issue Writer Certificate

Keywords

VACCINEQ2

BIOREACTOERQ2

SCHIZONT OF THEILERIA ANNULATAQ2

Abstract

Bovine Theileriosis have been producing in Iran nearly four decades. While Bovine Theileriosis VACCINE administration is now very crucial for disease control, therefore it is important to improve the quantity and quality of the VACCINE for providing the national and export markets. The growth ofTheileria annulata infected cell line S15 VACCINE strain in Stoker cell culture medium including 10% adult bovine serum in wolf simple cell culture vessel, Biomixer and in "Labfors" fully controlled aerobic bioreactor fed-batch system has revealed the efficient growth of T. annulata infected cell line in all employed vessels. The obtained results determined the 250% cell growth in "Wolf" vessel, 180% in Labfors aerobic bioreactor and finally 200% for Biomixer vessel. The results for quality control of produced VACCINE in proposed technique have shown the good quality of the prepared bovine Theileriosis VACCINE in aerobic bioreactor system.In conclusion, according to the achieved findings, the production of bovine Theileriosis VACCINE in aerobic bioreactor system might be used for high production and less manipulation of production processes as well as saving labor in order to mechanizing the production and better controlling the process of manufacturing.

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APA: Copy

HABIBI, GH., ESMAEIL NIA, K., IZADI, H., & BOZORGI, S.. (2015). STUDY ON CULTIVATION OF S15 VACCINE STRAIN CELL LINE IN AEROBIC BIOREACTOR FED-BATCH SYSTEM. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), 28(2(107)), 60-66. SID. https://sid.ir/paper/200959/en

Vancouver: Copy

HABIBI GH., ESMAEIL NIA K., IZADI H., BOZORGI S.. STUDY ON CULTIVATION OF S15 VACCINE STRAIN CELL LINE IN AEROBIC BIOREACTOR FED-BATCH SYSTEM. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI)[Internet]. 2015;28(2(107)):60-66. Available from: https://sid.ir/paper/200959/en

IEEE: Copy

GH. HABIBI, K. ESMAEIL NIA, H. IZADI, and S. BOZORGI, “STUDY ON CULTIVATION OF S15 VACCINE STRAIN CELL LINE IN AEROBIC BIOREACTOR FED-BATCH SYSTEM,” VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), vol. 28, no. 2(107), pp. 60–66, 2015, [Online]. Available: https://sid.ir/paper/200959/en

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