KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS

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POURALI SHESHBLOUKI GHOLAMREZA; MARDANEH J.; HOSSEINZADEH Z.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2016 | Volume:6 | Issue:1 Page(s): 52-59

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Title

KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS

Author(s)

POURALI SHESHBLOUKI GHOLAMREZA | MARDANEH J. | HOSSEINZADEH Z. | Issue Writer Certificate

Keywords

HOSPITALIZED PATIENTSQ1

BACTERIAL INFECTIONQ2

KLEBSIELLA PNEUMONIAEQ1

ANTIBIOTIC RESISTANCE PATTERNQ2

SUSCEPTIBLE-DOSE DEPENDENTQ2

Abstract

Background & Objective: Klebsiella pneumonia (K. pneumoniae) is a Gram-negative enteric bacterium that causes nosocomial infections. The aims of the present study were to identify KLEBSIELLA PNEUMONIAE infections in HOSPITALIZED PATIENTS: characterization of cross-resistance and ANTIBIOTIC RESISTANCE PATTERNs in isolates and detection of cefepime SUSCEPTIBLE-DOSE DEPENDENT in strains.Materials & Methods: In the present study (during 2014-2015), samples were collected from patients hospitalized in Ghotbadden, Faghihi and Nemazee hospitals (Shiraz, Iran). The isolates were identified as K. pneumoniae, based on the biochemical tests embedded in the API-20E system. The susceptibility testing (disc diffusion) was performed according to the clinical and laboratory standards institute guidelines (CLSI 2014). The dDetection of cefepime SUSCEPTIBLE-DOSE DEPENDENT (SDD) was performed. The detection of AmpC b-lactamases producing strains was done based on the cefoxitin and cefepime disk tests.Results: In this study 111 strains of KLEBSIELLA PNEUMONIAE were isolated. The less effective drug was ceftazidime (37.8% were sensitive). All SDD strains were susceptible to colistin and imipenem. Colistin (96.4%) and imipenem (88.3%) were the most effective antibiotics against isolates. Respectively, 41.4% and 35.1% isolates displayed resistance to gentamicin and amikacin. All colistin resistant isolates were imipenem sensitive.Conclusion: Carbapenem drugs are effective against Klebsieella pneumoniae infections. These results indicate that multidrug-resistant strains of K. pneumoniae are rising. The routine investigation and reporting of antibiotics resistance profile in patients presenting with Klebsiella infections is suggested.

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APA: Copy

POURALI SHESHBLOUKI, GHOLAMREZA, MARDANEH, J., & HOSSEINZADEH, Z.. (2016). KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 6(1), 52-59. SID. https://sid.ir/paper/203937/en

Vancouver: Copy

POURALI SHESHBLOUKI GHOLAMREZA, MARDANEH J., HOSSEINZADEH Z.. KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2016;6(1):52-59. Available from: https://sid.ir/paper/203937/en

IEEE: Copy

GHOLAMREZA POURALI SHESHBLOUKI, J. MARDANEH, and Z. HOSSEINZADEH, “KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 6, no. 1, pp. 52–59, 2016, [Online]. Available: https://sid.ir/paper/203937/en

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