THE COMPARISON OF THE EFFECT OF VITAMIN E ON THE EXPRESSION OF P53/PTEN OF PROSTATE GLAND OF MALE RATS IN TWO GROUPS OF INTENSIVE CONTINUOUS AND INTERMITTENT EXERCISE TRAINING

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DASHTIYAN A.; AFZALPOUR M.E.; TANIDEH N.; SEPEHRIMANESH M.

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Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2017 | Volume:7 | Issue:3 Page(s): 406-415

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Title

THE COMPARISON OF THE EFFECT OF VITAMIN E ON THE EXPRESSION OF P53/PTEN OF PROSTATE GLAND OF MALE RATS IN TWO GROUPS OF INTENSIVE CONTINUOUS AND INTERMITTENT EXERCISE TRAINING

Author(s)

DASHTIYAN A. | AFZALPOUR M.E. | TANIDEH N. | SEPEHRIMANESH M. | Issue Writer Certificate

Keywords

VITAMIN EQ2

CONTINUOUS TRAININGQ1

INTERMITTENT TRAININGQ1

P53Q2

PTENQ1

PROSTATE GLANDQ1

Abstract

Background & Objective: Physical activity and diet are the most important modifiable determinants of cancer risk. The aim of this study was to investigate the comparison of the effect of VITAMIN E on the expression of P53/PTEN PROSTATE GLAND of male rats in two groups of intensive continuous and intermittent exercise training.Materials & Methods: For this purpose, 56 male rats were randomly divided into 7 groups: [1] control group, [2] sham group, [3] intensive CONTINUOUS TRAINING, [4] intensive INTERMITTENT TRAINING, [5] intensive CONTINUOUS TRAINING+VITAMIN E, [6] intensive INTERMITTENT TRAINING+VITAMIN E, [7] VITAMIN E. The research training protocols were conducted in compliance with the principle of overload on the treadmill for six days a week, lasting 6 weeks. To measure expression changes of P53 and PTEN genes in rats' prostate, real-time PCR method was used and HPLC method was used to measure VITAMIN E. The One-way analysis of Variance test was used for comparisons among groups.Results: VITAMIN E in combination with CONTINUOUS TRAINING induced a significant decrease in the P53 gene expression of IIT+VE group (p>0.004) compared to the control group. In contrast, VITAMIN E in combination with INTERMITTENT TRAINING induced a significant decrease in expression of P53 (p>0.013) and a significant increase in the PTEN gene expression (p>0/035).Conclusion: The results showed that physical exercise training reduced PTEN and P53 tumor suppressing gene expression by reducing oxidative stress, and VITAMIN E can be a somewhat increased expression of these genes.

Cites

Twelve weeks of resistance training intervention on serum levels of some apoptosis markers in elderly men

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APA: Copy

DASHTIYAN, A., AFZALPOUR, M.E., TANIDEH, N., & SEPEHRIMANESH, M.. (2017). THE COMPARISON OF THE EFFECT OF VITAMIN E ON THE EXPRESSION OF P53/PTEN OF PROSTATE GLAND OF MALE RATS IN TWO GROUPS OF INTENSIVE CONTINUOUS AND INTERMITTENT EXERCISE TRAINING. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 7(3 ), 406-415. SID. https://sid.ir/paper/204026/en

Vancouver: Copy

DASHTIYAN A., AFZALPOUR M.E., TANIDEH N., SEPEHRIMANESH M.. THE COMPARISON OF THE EFFECT OF VITAMIN E ON THE EXPRESSION OF P53/PTEN OF PROSTATE GLAND OF MALE RATS IN TWO GROUPS OF INTENSIVE CONTINUOUS AND INTERMITTENT EXERCISE TRAINING. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2017;7(3 ):406-415. Available from: https://sid.ir/paper/204026/en

IEEE: Copy

A. DASHTIYAN, M.E. AFZALPOUR, N. TANIDEH, and M. SEPEHRIMANESH, “THE COMPARISON OF THE EFFECT OF VITAMIN E ON THE EXPRESSION OF P53/PTEN OF PROSTATE GLAND OF MALE RATS IN TWO GROUPS OF INTENSIVE CONTINUOUS AND INTERMITTENT EXERCISE TRAINING,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 7, no. 3 , pp. 406–415, 2017, [Online]. Available: https://sid.ir/paper/204026/en

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