THE EFFECT OF NICOTINE ON WEIGHT AND HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS’ EMBRYO

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ADINEH MARZIYEH; PAKPOUR BAHAREH; ESLAMI BAHMAN; NAVAEIAN MAJID

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Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:5 | Issue:15 Page(s): 75-82

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Title

THE EFFECT OF NICOTINE ON WEIGHT AND HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS’ EMBRYO

Author(s)

ADINEH MARZIYEH | PAKPOUR BAHAREH | ESLAMI BAHMAN | NAVAEIAN MAJID | Issue Writer Certificate

Keywords

EMBRYOQ1

RATQ2

NICOTINEQ2

WEIGHTQ2

HIPPOCAMPUSQ2

Abstract

Aim and Background: Intrauterine exposure to maternal tobacco smoking is associated with increased morbidity and mortality of the human infant. NICOTINE interacts with endogenous receptors in the brain and lung, and developmental exposure produces structural changes as well as alterations in neuroregulation. The present study evaluated the possible role of NICOTINE on the developing RAT fetus that include developing brain and fetus WEIGHT.Material and Methods: Wistar RATs (250-300 g) were used in this study. After pregnancy, the animals were divided into control and NICOTINE (0.3 mg/kg) in tap water groups. On 19th EMBRYOnic day, the RATs were killed and their EMBRYOs were surgically removed, washed, and their WEIGHT was measured and fixed in formalin 10%. Then tissue processing, cutting and Hematoxylin-Eosin (H&E) staining were preformed. The samples were evaluated using light microscope and MOTIC software for changes in HIPPOCAMPUS area. Data were analyzed using SPSS software version 9.01.Result: The WEIGHT of EMBRYOs decreased in the NICOTINE group. In addition, EMBRYOnic HIPPOCAMPUS layer the treatment group was change compared with the control group.Conclusion: It seems that NICOTINE induced its influence on EMBRYO development via different pathways and has a toxic effect on the brain.

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APA: Copy

ADINEH, MARZIYEH, PAKPOUR, BAHAREH, ESLAMI, BAHMAN, & NAVAEIAN, MAJID. (2014). THE EFFECT OF NICOTINE ON WEIGHT AND HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS’ EMBRYO. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(15), 75-82. SID. https://sid.ir/paper/204387/en

Vancouver: Copy

ADINEH MARZIYEH, PAKPOUR BAHAREH, ESLAMI BAHMAN, NAVAEIAN MAJID. THE EFFECT OF NICOTINE ON WEIGHT AND HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS’ EMBRYO. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;5(15):75-82. Available from: https://sid.ir/paper/204387/en

IEEE: Copy

MARZIYEH ADINEH, BAHAREH PAKPOUR, BAHMAN ESLAMI, and MAJID NAVAEIAN, “THE EFFECT OF NICOTINE ON WEIGHT AND HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS’ EMBRYO,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 15, pp. 75–82, 2014, [Online]. Available: https://sid.ir/paper/204387/en

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