EFFECTS OF HISTAMINE ON ANXIETY-RELATED BEHAVIOR IN MORPHINE SENSITIZED AND NAIVE RATS

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KHODARAHMI P.; ORYAN S.

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2011 | Volume:1 | Issue:1 Page(s): 53-58

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Title

EFFECTS OF HISTAMINE ON ANXIETY-RELATED BEHAVIOR IN MORPHINE SENSITIZED AND NAIVE RATS

Author(s)

KHODARAHMI P. | ORYAN S. | Issue Writer Certificate

Keywords

HISTAMINEQ2

ANXIETYQ2

SENSITIZATIONQ2

PLUS- MAZEQ3

RATQ2

Abstract

Aim and Background: It has been suggested that HISTAMINE have modulator influence on ANXIETY-related behaviors both in animals and humans. On the other hand, ventral hippocampus (VHC) may be an important brain site in the modulation of fear or ANXIETY.Materials and Methods: In the present study, the effects of bilateral intra-VHC injections of HISTAMINE on ANXIETY-related behavior have been investigated in morphine-sensitized and naive RATs using a plus-maze model. SENSITIZATION was obtained by subcutaneous injections of morphine, once daily for tree days and then five days free of the drug before test.Results: Our results showed bilateral intra-VHC administration of HISTAMINE (2.5, 5 and 7.5mg/rat) decreased %OAT (Open Arm Times) and %OAE (Open Arm Entries) but not locomotor activity that showing an anxiogenic effect. Another results indicated that morphine SENSITIZATION increased %OAT and %OAE.Conclusions:Bilateral intra-VHC administration of HISTAMINE showed an anxiogenic effect. Moreover, another results indicated that morphine SENSITIZATION indicated an anxiolytic response in the presence of HISTAMINE.

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APA: Copy

KHODARAHMI, P., & ORYAN, S.. (2011). EFFECTS OF HISTAMINE ON ANXIETY-RELATED BEHAVIOR IN MORPHINE SENSITIZED AND NAIVE RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 1(1), 53-58. SID. https://sid.ir/paper/204398/en

Vancouver: Copy

KHODARAHMI P., ORYAN S.. EFFECTS OF HISTAMINE ON ANXIETY-RELATED BEHAVIOR IN MORPHINE SENSITIZED AND NAIVE RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2011;1(1):53-58. Available from: https://sid.ir/paper/204398/en

IEEE: Copy

P. KHODARAHMI, and S. ORYAN, “EFFECTS OF HISTAMINE ON ANXIETY-RELATED BEHAVIOR IN MORPHINE SENSITIZED AND NAIVE RATS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 1, no. 1, pp. 53–58, 2011, [Online]. Available: https://sid.ir/paper/204398/en

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