THE STUDY OF THE ROLE OF GABAA RECEPTORS DURING FETAL DEVELOPMENT ON THE LEVELS OF CYTOKINES IN THE HIPPOCAMPUS AND PREFRONTAL CORTEX OF NMRI MOUSE OFF SPRINGS

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FATEHI GHAREHLAR LALEH; YAGHMAEI PARICHEHREH; PARIVAR KAZEM; EBRAHIM HABIBI AZADEH; MALEKI MASOUD

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2015 | Volume:5 | Issue:20 Page(s): 71-78

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Title

THE STUDY OF THE ROLE OF GABAA RECEPTORS DURING FETAL DEVELOPMENT ON THE LEVELS OF CYTOKINES IN THE HIPPOCAMPUS AND PREFRONTAL CORTEX OF NMRI MOUSE OFF SPRINGS

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Keywords

GABAA-RQ2

CYTOKINEQ1

RATQ2

Abstract

Aim and Background: Manystudies have found an association between inflammation and mental disorders such as anxiety and depressionin different regions of the brain. Inflammatory factors cause increase in CYTOKINEs levels. On the other hand elevated levels of CYTOKINE are associated with several neurological disorders, including anxiety, depression, Alzheimer and Parkinson’s diseases. GABA (Gamma Aminobutyric acid) is a majorinhibitory neurotransmitter in the mammalian central nervous system. Many studies have proven the roleof GABA in mental disorders including anxiety, depression. The present study investigates the effects of GABA agonists and antagonistson the levels of inflammatory factors and CYTOKINEs levels in off springs.Materials and Methods: In the present study, the pregnant female RATs in their late pregnancy were treated for 3 days, from 16th to 18th day of gestation, with the antagonist or agonist GABAa receptor with 10, 50, 100, 500 and 700 mg / kg of Muscimol and 20, 70, 140, 500 and 800 mg / kg of Bicuculline. After the treatment, the CYTOKINEs levels in the hippocampus and prefrontal cortex were measured in offsprings. The measurement was carried out by ELIZA technique.Results: Our results showed that the treatment on pregnant female RATs in their late pregnancy (16th to 18th day of gestation for 3 days(with antagonist (bicuculline) or agonist (muscimol) of GABAa receptor which were 500 and 700 mg / kg for muscimol 140 and 500 mg / kg for bicuculline, had no effect on the levels of CYTOKINEs.Conclusion: In conclusion, these studies showed that the blockage of GABA receptor plays no role in the inflammatory factors and CYTOKINEs.

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APA: Copy

FATEHI GHAREHLAR, LALEH, YAGHMAEI, PARICHEHREH, PARIVAR, KAZEM, EBRAHIM HABIBI, AZADEH, & MALEKI, MASOUD. (2015). THE STUDY OF THE ROLE OF GABAA RECEPTORS DURING FETAL DEVELOPMENT ON THE LEVELS OF CYTOKINES IN THE HIPPOCAMPUS AND PREFRONTAL CORTEX OF NMRI MOUSE OFF SPRINGS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(20), 71-78. SID. https://sid.ir/paper/204447/en

Vancouver: Copy

FATEHI GHAREHLAR LALEH, YAGHMAEI PARICHEHREH, PARIVAR KAZEM, EBRAHIM HABIBI AZADEH, MALEKI MASOUD. THE STUDY OF THE ROLE OF GABAA RECEPTORS DURING FETAL DEVELOPMENT ON THE LEVELS OF CYTOKINES IN THE HIPPOCAMPUS AND PREFRONTAL CORTEX OF NMRI MOUSE OFF SPRINGS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2015;5(20):71-78. Available from: https://sid.ir/paper/204447/en

IEEE: Copy

LALEH FATEHI GHAREHLAR, PARICHEHREH YAGHMAEI, KAZEM PARIVAR, AZADEH EBRAHIM HABIBI, and MASOUD MALEKI, “THE STUDY OF THE ROLE OF GABAA RECEPTORS DURING FETAL DEVELOPMENT ON THE LEVELS OF CYTOKINES IN THE HIPPOCAMPUS AND PREFRONTAL CORTEX OF NMRI MOUSE OFF SPRINGS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 20, pp. 71–78, 2015, [Online]. Available: https://sid.ir/paper/204447/en

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