DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS

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BAGHERI GITA; ABEDIN DORKOOSH FARID; VASHEGHANI FARAHANI EBRAHIM; ARDJMAND MEHDI

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2015 | Volume:5 | Issue:17 Page(s): 81-88

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Title

DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS

Author(s)

BAGHERI GITA | ABEDIN DORKOOSH FARID | VASHEGHANI FARAHANI EBRAHIM | ARDJMAND MEHDI | Issue Writer Certificate

Keywords

OLANZAPINEQ2

GLYCEROL MONOOLEATEQ2

CUBIC PHASEQ2

IN VITRO RELEASEQ2

RESPONSE SURFACE METHODOLOGY BOX- BEHNKENQ2

Abstract

Backgrounds and Objectives: This research is to develop new systems for drug release systems based on sol - gel systems. The objective of this study is to develop controlled release formulation of water insoluble OLANZAPINE (OZ), using GLYCEROL MONOOLEATE (GMO) and Polyethylene glycol (PEG 300).Materials and Methods: A Box- Behnken response surface methodology was applied to design gel system with 3 factors with an initial drug containing, weight ratio of GMO/water (w/w) and weight ratio of PEG 300/GMO (w/w).Results: Therefore, in this study Design-ExpertÒ software with Box- Behnken response surface methodology has been used specifically to determine the relationships between variables and responses.Discussion: According to the results of experiments, a quadratic model as an appropriate equation has been selected to fit the percentage of loading. Percentage of release at 12th and 168th hr a cubic model is selected. Kinetic release profile of OZ was investigated with several models, from which Higuchi model showed the best fitting and highest correlation.Conclusion: Optimization of gel system was carried out based on statistical concept of experimental design. Validation test was carried out under optimum conditions of the parameters predicted by the polynomial model.

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APA: Copy

BAGHERI, GITA, ABEDIN DORKOOSH, FARID, VASHEGHANI FARAHANI, EBRAHIM, & ARDJMAND, MEHDI. (2015). DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(17), 81-88. SID. https://sid.ir/paper/204575/en

Vancouver: Copy

BAGHERI GITA, ABEDIN DORKOOSH FARID, VASHEGHANI FARAHANI EBRAHIM, ARDJMAND MEHDI. DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2015;5(17):81-88. Available from: https://sid.ir/paper/204575/en

IEEE: Copy

GITA BAGHERI, FARID ABEDIN DORKOOSH, EBRAHIM VASHEGHANI FARAHANI, and MEHDI ARDJMAND, “DESIGN OF CONTROLLED RELEASE OF OLANZAPINE BY USING GLYCEROL MONOOLEATE IN SOL-GEL SYSTEMS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 17, pp. 81–88, 2015, [Online]. Available: https://sid.ir/paper/204575/en

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