INVESTIGATION THE EFFECTS OF SILVER NANO PARTICLES ON OVARY TISSUE AND HPG AXIS IN RATS

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RAMEZANI MINA; REZAEI SAEED; NASRI SIMA

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:24 Page(s): 37-42

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Title

INVESTIGATION THE EFFECTS OF SILVER NANO PARTICLES ON OVARY TISSUE AND HPG AXIS IN RATS

Author(s)

RAMEZANI MINA | REZAEI SAEED | NASRI SIMA | Issue Writer Certificate

Keywords

SILVER NANO PARTICLESQ1

HPG AXISQ1

OVARYQ1

RATQ2

Abstract

Aim and Background: By attention to extensive use of Silver nanoparticles, this study has been done to investigate the effects of silver these particles on OVARY tissue and HPG AXIS.Materials and Methods: Adult female RATs were divided into five groups. Treatment groups received 25, 50, 100, and 200 mg/kg/day SILVER NANO PARTICLES for 30 days orally. Then the RATs weighed and levels of FSH, LH, estrogen, and progesterone were measured. Ovaries sections were studied using light microscopy.Results: The weight of RATs and their ovaries, the level of FSH, LH, and Estrogen of serum decreased significantly in 50, 100, and 200 mg/kg doses in comparison with the control (p<0.05). However, progesterone almost remained unaffected. OVARY tissue examination in the group that had been given a high dose of silver nanoparticles indicated extensive congestion comparing with control. Moreover, the number of the follicles had been reduced. These results were also observable in lower doses in moderate degree.Conclusion: Results have indicated poisonous effects of silver nanoparticles on HPG-axis and OVARY tissue that is dose dependent. Therefore, enough precaution must be down in chronic exposure of females.

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APA: Copy

RAMEZANI, MINA, REZAEI, SAEED, NASRI, SIMA, & HOOSHYAR, LEILA. (2016). INVESTIGATION THE EFFECTS OF SILVER NANO PARTICLES ON OVARY TISSUE AND HPG AXIS IN RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(24), 37-42. SID. https://sid.ir/paper/204578/en

Vancouver: Copy

RAMEZANI MINA, REZAEI SAEED, NASRI SIMA, HOOSHYAR LEILA. INVESTIGATION THE EFFECTS OF SILVER NANO PARTICLES ON OVARY TISSUE AND HPG AXIS IN RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(24):37-42. Available from: https://sid.ir/paper/204578/en

IEEE: Copy

MINA RAMEZANI, SAEED REZAEI, SIMA NASRI, and LEILA HOOSHYAR, “INVESTIGATION THE EFFECTS OF SILVER NANO PARTICLES ON OVARY TISSUE AND HPG AXIS IN RATS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 24, pp. 37–42, 2016, [Online]. Available: https://sid.ir/paper/204578/en

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