INNATE IMMUNITY ACTIVATED VIA SIRNA

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MOHAJERI N.; KAZEMI B.

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Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2011 | Volume:1 | Issue:3 Page(s): 7-16

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Information Journal Paper

Title

INNATE IMMUNITY ACTIVATED VIA SIRNA

Author(s)

MOHAJERI N. | KAZEMI B. | Issue Writer Certificate

Keywords

DSRNAQ2

SIRNAQ2

INNATE IMMUNITY RESPONSEQ2

Abstract

Aim and Background: RNA interference has the role of gene silencing process that is triggered by double-stranded RNAs. Common to all cell types, is the production of 21-24 nucleotide small interfering RNA (siRNA), which guides the RNA-induced silencing complex (RISC) to identify and cleave target mRNA sequences. SIRNA duplex are potent activators of innate immune system that induce high levels of cytokines and interferon. Toll-like receptors trigger the first line of innate immune response that is mediated by transcriptional induction of a large number of cellular genes. SIRNA interact with cytoplasmic RNA sensors such as: Retinoic - acid Inducible Gene -I (RIG-I), RNA-Activated protein kinase R (PKR), Interferon Regulatory Factor (IRF) and 2’ -5’ oligo adenylate synthetase (2’ -5’ OAS), Nuclear Factor kappa B cell (NF-kB). SIRNA modification are on the sugar, phosphate linkage, base, overhangs and termini nucleotides leading to increase half-life SIRNA. This review article describes gene silencing and innate immune caused by SIRNA.

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APA: Copy

MOHAJERI, N., & KAZEMI, B.. (2011). INNATE IMMUNITY ACTIVATED VIA SIRNA. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 1(3), 7-16. SID. https://sid.ir/paper/204635/en

Vancouver: Copy

MOHAJERI N., KAZEMI B.. INNATE IMMUNITY ACTIVATED VIA SIRNA. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2011;1(3):7-16. Available from: https://sid.ir/paper/204635/en

IEEE: Copy

N. MOHAJERI, and B. KAZEMI, “INNATE IMMUNITY ACTIVATED VIA SIRNA,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 1, no. 3, pp. 7–16, 2011, [Online]. Available: https://sid.ir/paper/204635/en

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