GLIOBLASTOMA MICROVESICLES TRANSPORT RNA AND PROTEINS THAT PROMOTE TUMOUR GROWTH AND PROVIDE DIAGNOSTIC BIOMARKERS

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CHESHMI H.

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Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2011 | Volume:1 | Issue:3 Page(s): 75-88

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Information Journal Paper

Title

GLIOBLASTOMA MICROVESICLES TRANSPORT RNA AND PROTEINS THAT PROMOTE TUMOUR GROWTH AND PROVIDE DIAGNOSTIC BIOMARKERS

Author(s)

CHESHMI H. | Issue Writer Certificate

Keywords

GLIOBLASTOMAQ2

MIRNAQ1

EGFRVIIIQ2

MICROVESICLEQ2

Abstract

Aim and Background: GLIOBLASTOMA tumour cells release MICROVESICLEs (exosomes) containing mRNA, MIRNA and angiogenic proteins. These MICROVESICLEs are taken up by normal host cells, such as brain microvascular endothelial cells.Materials and methods: By incorporating an mRNA for a reporter protein into these MICROVESICLEs, we demonstrate that messages delivered by MICROVESICLEs are translated by recipient cells. These MICROVESICLEs are also enriched in angiogenic proteins and stimulate tubule formation by endothelial cells.Results: Tumour-derived MICROVESICLEs therefore serve as a means of delivering genetic information and proteins to recipient cells in the tumour environment. GLIOBLASTOMA MICROVESICLEs also stimulated proliferation of a human glioma cell line, indicating a self-promoting aspect. Messenger RNA mutant/variants and MIRNAs characteristic of gliomas could be detected in serum MICROVESICLEs of GLIOBLASTOMA patients. The tumour-specific EGFRVIII was detected in serum MICROVESICLEs from 7 out of 25 GLIOBLASTOMA patients.Conclusion: The tumour-specific EGFRVIII was detected in serum MICROVESICLEs from 7 out of 25 GLIOBLASTOMA patients. Thus, tumour-derived MICROVESICLEs may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test.

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APA: Copy

CHESHMI, H.. (2011). GLIOBLASTOMA MICROVESICLES TRANSPORT RNA AND PROTEINS THAT PROMOTE TUMOUR GROWTH AND PROVIDE DIAGNOSTIC BIOMARKERS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 1(3), 75-88. SID. https://sid.ir/paper/204637/en

Vancouver: Copy

CHESHMI H.. GLIOBLASTOMA MICROVESICLES TRANSPORT RNA AND PROTEINS THAT PROMOTE TUMOUR GROWTH AND PROVIDE DIAGNOSTIC BIOMARKERS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2011;1(3):75-88. Available from: https://sid.ir/paper/204637/en

IEEE: Copy

H. CHESHMI, “GLIOBLASTOMA MICROVESICLES TRANSPORT RNA AND PROTEINS THAT PROMOTE TUMOUR GROWTH AND PROVIDE DIAGNOSTIC BIOMARKERS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 1, no. 3, pp. 75–88, 2011, [Online]. Available: https://sid.ir/paper/204637/en

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