THE EFFECT OF BENZODIAZEPINE ON ANXIETY AND INTERACTION BETWEEN BENZODIAZEPINE AND HISTAMINE IN ELEVATED PLUS-MAZE MODEL OF THE RATS

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KHODARAHMI PARVIN; SARAHROODI SHADI

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2013 | Volume:3 | Issue:11 Page(s): 55-61

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Title

THE EFFECT OF BENZODIAZEPINE ON ANXIETY AND INTERACTION BETWEEN BENZODIAZEPINE AND HISTAMINE IN ELEVATED PLUS-MAZE MODEL OF THE RATS

Author(s)

KHODARAHMI PARVIN | SARAHROODI SHADI | Issue Writer Certificate

Keywords

HISTAMINEQ2

DIAZEPAMQ2

ANXIETYQ2

PLUS-MAZE TESTQ2

INTRAPERITONEALQ2

RATQ2

Abstract

Aim and Background: It has been suggested that HISTAMINE has modulatory influence on ANXIETY-related behaviors both in animals and humans. On the other hand, GABA (A) receptor modulating drugs such as benzodiazepines have been used to treat ANXIETY disorders. Co-administration of the aforementioned drugs would be of high interest in terms of ANXIETY effects.Materials and methods: In the present study, we investigated the ANXIETY-related effects of individual and combined INTRAPERITONEALly administration of HISTAMINE and DIAZEPAM, a benzodiazepine agent. To do so, anxiolytic indices of Open Arm Times (%OAT) and Open Arm Entries (%OAE) were measured using an elevated PLUS-MAZE TEST of ANXIETY on RATs.Results: INTRAPERITONEAL HISTAMINE administration 20 (mg/kg) decreased %OAT, but not locomotor activity, showing an anxiogenic response. Subcutaneous administration of DIAZEPAMe at dose of 1 mg/kg increased %OAT and %OAE, but not locomotor activity, showing an anxiolytic response. Subcutaneous administration of DIAZEPAMe, at doses of 1 mg/kg before HISTAMINE (20 mg/kg) increased %OAT and %OAE but not locomotor activity, thus showing an anxiolytic response.Conclusion: Our results indicated that the anxiogenic effects induced by HISTAMINE in the INTRAPERITONEAL could be reversed in the presence of DIAZEPAM.

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APA: Copy

KHODARAHMI, PARVIN, & SARAHROODI, SHADI. (2013). THE EFFECT OF BENZODIAZEPINE ON ANXIETY AND INTERACTION BETWEEN BENZODIAZEPINE AND HISTAMINE IN ELEVATED PLUS-MAZE MODEL OF THE RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 3(11), 55-61. SID. https://sid.ir/paper/204646/en

Vancouver: Copy

KHODARAHMI PARVIN, SARAHROODI SHADI. THE EFFECT OF BENZODIAZEPINE ON ANXIETY AND INTERACTION BETWEEN BENZODIAZEPINE AND HISTAMINE IN ELEVATED PLUS-MAZE MODEL OF THE RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2013;3(11):55-61. Available from: https://sid.ir/paper/204646/en

IEEE: Copy

PARVIN KHODARAHMI, and SHADI SARAHROODI, “THE EFFECT OF BENZODIAZEPINE ON ANXIETY AND INTERACTION BETWEEN BENZODIAZEPINE AND HISTAMINE IN ELEVATED PLUS-MAZE MODEL OF THE RATS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 3, no. 11, pp. 55–61, 2013, [Online]. Available: https://sid.ir/paper/204646/en

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