INVESTIGATION OF EFFECTIVE FACTORS IN PREPARATION OF POLYBUTYL CYANOACRYLATE NANOPARTICLES BY EMULSION POLYMERIZATION

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EBRAHIMI SHAHMABADI HASAN; RASOULI RAHIMEH; ALAVI SEYED EBRAHIM; AKBARZADEH AZIM; KOOHI MOFTAKHARI ESFAHANI MAEDEH

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2015 | Volume:5 | Issue:19 Page(s): 33-38

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Title

INVESTIGATION OF EFFECTIVE FACTORS IN PREPARATION OF POLYBUTYL CYANOACRYLATE NANOPARTICLES BY EMULSION POLYMERIZATION

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Keywords

NANOQ2

POLY BUTYL CYANOACRYLATEQ2

DEXTRANQ2

EMULSION POLYMERIZATIONQ2

Abstract

Aim and Background: In recent decades, drug carriers in NANO scale have been focus of attentions. In last two decades, cyanoacrylate NANOparticles have been widely studied as drug NANOcarriers. In this work, production of polybutyl cyanoacrylate (PBCA) NANOparticles by EMULSION POLYMERIZATION has been investigated.Material and Methods: polybutyl cyanoacrylate NANOparticles were produced by EMULSION POLYMERIZATION using 70 KDa DEXTRAN as stabilizer. NANOparticles were described by Zeta sizer, scanning electron microscope and light microscope. Effect of polymerization factors on size and distribution of particles, was studied. Such factors include 70 KDa DEXTRAN, polysorbate-80, concentration of H+ion, polymerization time, temperature and sonication.Results: This study indicates that a definite portion of stabilizer is essential for the production of NANOparticles. This concentration was recognized to be 2%. Effect of H+ion was considerable as a sharp decrease was observed in pH 4. In comparison with room temperature, higher size and distribution of NANOparticles was gained in temperature of 50 °C. Effect of polysorbate-80 in concentration of 0.001% on NANOparticles was evaluated to be positive. Furthermore, increasing polymerization time from 5.5 to 18 hours resulted in synthesis of more appropriate NANOparticles.Discussion: The results illustrate that NANOparticles properties depend on various factors and manipulation of such factors can result in desirable properties.Conclusion: PBCA NANOparticles are under the influence of various factors and we can make an acceptable and desirable NANOparticle by their proper manipulation.

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APA: Copy

EBRAHIMI SHAHMABADI, HASAN, RASOULI, RAHIMEH, ALAVI, SEYED EBRAHIM, AKBARZADEH, AZIM, & KOOHI MOFTAKHARI ESFAHANI, MAEDEH. (2015). INVESTIGATION OF EFFECTIVE FACTORS IN PREPARATION OF POLYBUTYL CYANOACRYLATE NANOPARTICLES BY EMULSION POLYMERIZATION. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(19), 33-38. SID. https://sid.ir/paper/204650/en

Vancouver: Copy

EBRAHIMI SHAHMABADI HASAN, RASOULI RAHIMEH, ALAVI SEYED EBRAHIM, AKBARZADEH AZIM, KOOHI MOFTAKHARI ESFAHANI MAEDEH. INVESTIGATION OF EFFECTIVE FACTORS IN PREPARATION OF POLYBUTYL CYANOACRYLATE NANOPARTICLES BY EMULSION POLYMERIZATION. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2015;5(19):33-38. Available from: https://sid.ir/paper/204650/en

IEEE: Copy

HASAN EBRAHIMI SHAHMABADI, RAHIMEH RASOULI, SEYED EBRAHIM ALAVI, AZIM AKBARZADEH, and MAEDEH KOOHI MOFTAKHARI ESFAHANI, “INVESTIGATION OF EFFECTIVE FACTORS IN PREPARATION OF POLYBUTYL CYANOACRYLATE NANOPARTICLES BY EMULSION POLYMERIZATION,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 19, pp. 33–38, 2015, [Online]. Available: https://sid.ir/paper/204650/en

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