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Information Journal Paper

Title

THE STUDY OF TOXICITY AND TERATOGENIC EFFECTS OF NERIUM OLEANDER LEAVE’S EXTRACT ON CHICKEN EMBRYO

Pages

  69-75

Abstract

 Aims and Background: NERIUM OLEANDER is a medicinal plant with various biological activities such as antibacterial, antioxidant and cytotoxic effects. In the present work, methanolic extract of plant was used for the evaluation of TOXICITY and teratogenic effects on chicken embryo as an animal model.Materials and Methods: Methanolic extracts were prepared. Methanolic extract solutions in DMSO were injected in air sac of chicken eggs at concentrations of 5, 10, 20, 40, 60 and 80 mg/egg. Seventy two hours after incubation, eggs were placed at 37.7-38oC incubator.Results: On the day 19 after incubation, eggs were opened and shown that 78.4, 65, 56.7, 46.7, 31.66 and 21.66 percent of embryos were alive, Results showed that LD50 was at the concentration of 43.60mg/egg. Morphological and skeletal abnormalities in the treatment groups showed that club foot and beak deformity were occurred in morphology while caudal vertebrate deletions, unossification or uncalcification of caudal vertebrates were appeared in skeleton of the Chickens.Conclusion: The study of methanolic extract showed that, with increasing concentration, mortality increased. The extract in low concentrations had negligible TOXICITY and teratogenic effects which can be used as therapeutic aims.

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    APA: Copy

    FAROOGHI, NASRIN, MALEKI, MASOUD, GHASEMI GERMI, KARIMOLLAH, & ABDOLMALEKI, ARASH. (2015). THE STUDY OF TOXICITY AND TERATOGENIC EFFECTS OF NERIUM OLEANDER LEAVE’S EXTRACT ON CHICKEN EMBRYO. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(19), 69-75. SID. https://sid.ir/paper/204652/en

    Vancouver: Copy

    FAROOGHI NASRIN, MALEKI MASOUD, GHASEMI GERMI KARIMOLLAH, ABDOLMALEKI ARASH. THE STUDY OF TOXICITY AND TERATOGENIC EFFECTS OF NERIUM OLEANDER LEAVE’S EXTRACT ON CHICKEN EMBRYO. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2015;5(19):69-75. Available from: https://sid.ir/paper/204652/en

    IEEE: Copy

    NASRIN FAROOGHI, MASOUD MALEKI, KARIMOLLAH GHASEMI GERMI, and ARASH ABDOLMALEKI, “THE STUDY OF TOXICITY AND TERATOGENIC EFFECTS OF NERIUM OLEANDER LEAVE’S EXTRACT ON CHICKEN EMBRYO,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 19, pp. 69–75, 2015, [Online]. Available: https://sid.ir/paper/204652/en

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