Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2, oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens

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Kangavari Sepideh; shaheli Marjan; rezaeian Abbasali

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2019 | Volume:9 | Issue:34 Page(s): 37-45

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Title

Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2, oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens

Author(s)

Kangavari Sepideh | shaheli Marjan | rezaeian Abbasali | Issue Writer Certificate

Keywords

Integron class 1Q1

PseudomonasQ2

MDRQ2

OXA-2Q1

OXA-10Q1

Abstract

Aim and Background: Eradicating infections is difficult due to the presence of genes on the introns, especially the beta-lactamase enzymes and The importance of their resistance is high. The purpose of this study was to determine the beta-lactamase genes (OXA-2, OXA-10), Integron class 1 and antibiotic resistance. Material and methods: In this cross sectional descriptive study, 120 Pseudomonas isolates were collected from Shiraz Burn Hospital during summer of 1395. After confirmation by biochemical tests, The presence of beta-lactamase genes was evaluated by using antibiotic discs and PCR method. Results: 78. 5% of the isolates had OXA-10 gene, 77. 57% of the OXA-2 gene, 34. 58% containing Int1, and 95. 38% of the samples were MDR. Maximum resistant was seen in cefepime(79. 43%) and the minimum was for to tobramycin(10. 28%). Conclusion: Class1 integron, 2-oxa and 10-oxa beta-lactamase genes, did not show up a meaningful relationship at the same time. the production of beta-lactamase enhances the increasing resistance and their frequency is increasing according to the results of other studies. This will lead more control over the prescription and use of antibiotics.

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APA: Copy

Kangavari, Sepideh, shaheli, Marjan, & rezaeian, Abbasali. (2019). Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2, oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 9(34 ), 37-45. SID. https://sid.ir/paper/204714/en

Vancouver: Copy

Kangavari Sepideh, shaheli Marjan, rezaeian Abbasali. Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2, oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2019;9(34 ):37-45. Available from: https://sid.ir/paper/204714/en

IEEE: Copy

Sepideh Kangavari, Marjan shaheli, and Abbasali rezaeian, “Role of class 1 Integron in prevalence extended-spectrum beta-lactamases of class D (oxa-2, oxa-10) along with determining antibiotic resistance pattern in Pseudomonas strains isolated from clinical specimens,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 9, no. 34 , pp. 37–45, 2019, [Online]. Available: https://sid.ir/paper/204714/en

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