ANTIOXIDANT INDEX EVALUATION IN THE RAT EMBRYO INDUCED BY NANO-SILVER PARTICLE

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HONARVAR FATEMEH; VAEZI GHOLAMHOSSEIN; NOURANI MOHAMMADREZA; KAMRANI ASEFEH; SADEGHNEZHAD EHSAN

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:23 Page(s): 53-60

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Title

ANTIOXIDANT INDEX EVALUATION IN THE RAT EMBRYO INDUCED BY NANO-SILVER PARTICLE

Author(s)

Keywords

NANO-SILVERQ1

RATQ2

LIVER EMBRYOQ1

OXIDATIVE STRESSQ1

Abstract

Aim and Background: NANO-SILVER as a disinfectant is used for the sterilization of medical laboratory tools, but less attention has been tentative the toxicity of the substance. The aim of this study was to evaluate the effects of Nanosilver on fetal RAT liver tissue and determine the expression of MDA levels as an oxidant biomarker and Superoxide dismutase as an antioxidant enzyme. Material and methods: In this study, 16 pregnant Wister RATs (four groups of four each) and placebo were treated orally for 18 days with silver nanoparticles of 20 nm in concentration of 125, 750 and 1500 mg / kg / day. The fetuses had been harvested via caesarean after 18 days of gestation to measure the gene expression of SOD in their liver by quantitative RT-PCR method and MDA activity by Satoh protocol in their liver.Results: The highest expression of MDA was detected in the treatment of 750 mg / kg / day, but in comparison to the normal group which showed approximately 68% decrease in concentration. The highest expression of SOD was related to 750 mg/kg/day group which was upregulated 22.4% in compare to normal group, and the lowest expression was shown in 125 mg/kg/day group which was approximately down regulated 5.75 % in compare to normal group.Conclusion: Nano silver particles involved in the process of oxidative/antioxidant system that is caused by arise of free radical production. Antioxidant enzymes such as superoxide dismutase as free radical scavenger was up regulated to detoxify microenvironment. The result of this study revealed that intracellular processes of oxidant/antioxidant system in RAT embryo liver were affected by various concentrations of Nano silver particles.

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References

TYPE A BOTULISM IN MEMBERS OF A FAMILY FOLLOWING THE CONSUMPTION OF LOCALLY MADE CHEESE (CASE REPORT)

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APA: Copy

HONARVAR, FATEMEH, VAEZI, GHOLAMHOSSEIN, NOURANI, MOHAMMADREZA, KAMRANI, ASEFEH, & SADEGHNEZHAD, EHSAN. (2016). ANTIOXIDANT INDEX EVALUATION IN THE RAT EMBRYO INDUCED BY NANO-SILVER PARTICLE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(23), 53-60. SID. https://sid.ir/paper/204730/en

Vancouver: Copy

HONARVAR FATEMEH, VAEZI GHOLAMHOSSEIN, NOURANI MOHAMMADREZA, KAMRANI ASEFEH, SADEGHNEZHAD EHSAN. ANTIOXIDANT INDEX EVALUATION IN THE RAT EMBRYO INDUCED BY NANO-SILVER PARTICLE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(23):53-60. Available from: https://sid.ir/paper/204730/en

IEEE: Copy

FATEMEH HONARVAR, GHOLAMHOSSEIN VAEZI, MOHAMMADREZA NOURANI, ASEFEH KAMRANI, and EHSAN SADEGHNEZHAD, “ANTIOXIDANT INDEX EVALUATION IN THE RAT EMBRYO INDUCED BY NANO-SILVER PARTICLE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 23, pp. 53–60, 2016, [Online]. Available: https://sid.ir/paper/204730/en

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