FORMULATION OF TOPICAL HYDRO ALCOHOLIC GEL CONTAINING INDOMETHACIN 0.2% USING CARBOXY METHYL CELLULOSE AND HYDROXYL PROPYL CELLULOSE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOGHIMIPOUR ESKANDAR; SALIMI ANAYATOLLAH; HAJ MOHAMMADI AKRAM; HAJ MOHAMMADI MEHDI; HAJ MOHAMMADI MOSTAFA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2012 | Volume:3 | Issue:2 (7) Page(s): 339-349

Download Full-Text

Persian Verion

View:

2,355

Download:

Cites:

Information Journal Paper

Title

FORMULATION OF TOPICAL HYDRO ALCOHOLIC GEL CONTAINING INDOMETHACIN 0.2% USING CARBOXY METHYL CELLULOSE AND HYDROXYL PROPYL CELLULOSE

Author(s)

Keywords

INDOMETHACINQ3

POLYMERQ3

GELQ3

TOPICAL FORMULATIONQ3

Abstract

Background: INDOMETHACIN is a NSAID (non-steroidal antiinflammatory drug) that is used in treatment of pain and inflammatory. Immediate and sustained release products of this drug have side effects, so a proper replacement is needed. Use of the medicine via topical and cutaneous routs has advantages such as avoiding side effects on gastrointestinal; and supplying an amount of medicine in plasma for long time. The purpose of the present study was production and evaluation of the topical GEL of INDOMETHACIN with an appropriate appearance and stability to reduce side effects especially on gastrointestinal and to deliver enough amount of the drug to target site. Methods: First the standard curve of INDOMETHACIN was plotted and then GELs with different concentration of CMC and HPC was prepared. After the examination the appearance and stability of different formulations, the best formulations were chosen and rheology, stability and release experiments were done. Results: 5% HPC and 2.5% CMC were chosen as the best percentages of these POLYMERs to prepare formulation of INDOMETHACIN. Release drug from these formulations followed a first order rate and rheograms of both formulae showed a mild plastic behavior. Conclusion: According to the data obtained from the study, the best results were obtained with HPC POLYMER so that with increasing concentration, transparency and viscosity was much better but in concentration more than 5% the quality of the GELs decreased.

Cites

No record.

References

No record.

Cite

APA: Copy

MOGHIMIPOUR, ESKANDAR, SALIMI, ANAYATOLLAH, HAJ MOHAMMADI, AKRAM, HAJ MOHAMMADI, MEHDI, & HAJ MOHAMMADI, MOSTAFA. (2012). FORMULATION OF TOPICAL HYDRO ALCOHOLIC GEL CONTAINING INDOMETHACIN 0.2% USING CARBOXY METHYL CELLULOSE AND HYDROXYL PROPYL CELLULOSE. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 3(2 (7)), 339-349. SID. https://sid.ir/paper/205741/en

Vancouver: Copy

MOGHIMIPOUR ESKANDAR, SALIMI ANAYATOLLAH, HAJ MOHAMMADI AKRAM, HAJ MOHAMMADI MEHDI, HAJ MOHAMMADI MOSTAFA. FORMULATION OF TOPICAL HYDRO ALCOHOLIC GEL CONTAINING INDOMETHACIN 0.2% USING CARBOXY METHYL CELLULOSE AND HYDROXYL PROPYL CELLULOSE. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2012;3(2 (7)):339-349. Available from: https://sid.ir/paper/205741/en

IEEE: Copy

ESKANDAR MOGHIMIPOUR, ANAYATOLLAH SALIMI, AKRAM HAJ MOHAMMADI, MEHDI HAJ MOHAMMADI, and MOSTAFA HAJ MOHAMMADI, “FORMULATION OF TOPICAL HYDRO ALCOHOLIC GEL CONTAINING INDOMETHACIN 0.2% USING CARBOXY METHYL CELLULOSE AND HYDROXYL PROPYL CELLULOSE,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 3, no. 2 (7), pp. 339–349, 2012, [Online]. Available: https://sid.ir/paper/205741/en

Related Journal Papers