GALANIN OR MORPHINE SIGNIFICANTLY DECREASED THYROID HORMONES CONCENTRATION AFTER INJECTIONS COMPARED TO BEFORE INJECTION

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HAGHNAZARI FARZANEH; KHAZALI HOMAYOUN; TAGHVIYATI SINA

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Journal: JOURNAL OF ANIMAL ENVIRONMENT Year:2016 | Volume:8 | Issue:2 Page(s): 47-52

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Title

GALANIN OR MORPHINE SIGNIFICANTLY DECREASED THYROID HORMONES CONCENTRATION AFTER INJECTIONS COMPARED TO BEFORE INJECTION

Author(s)

HAGHNAZARI FARZANEH | KHAZALI HOMAYOUN | TAGHVIYATI SINA | Issue Writer Certificate

Keywords

GALANINQ1

MORPHINEQ1

T3Q1

T4Q1

ICV INJECTIONQ1

Abstract

Previous studies have shown that GALANIN is an orexigenic peptide that inhibits the activity of Hypothalamus –Pituitary – Thyroid (HPT) axis. It is also proved that GALANIN increases food intake via neuropeptide Y pathway. MORPHINE is an alkaloid opiates that effect on thyroid hormones concentration via Agouti Related Protein and increases dopaminergic neurons activity in median eminence. The aim of this study was to determine the influence of the interaction between GALANIN and MORPHINE on thyroid hormones concentration. Twenty-one male Wistar rats (200-250 g) were randomly divided 3 groups. The groups received 200ng GALANIN, 1mg MORPHINE and 200ng GALANIN together with 1mg MORPHINE in third cerebral ventricle in volumes of 3 ml. Blood samples were collected one day before injection and untill 24 hours after that. The plasma was analyzed by Radioimmunoassay technique to determine T3 and T4 concentrations. Brain slices were taken to ensure that the place of the canulae was right. The results indicated that GALANIN or MORPHINE significantly decreased thyroid hormones concentration after injections compared to before injection (p<0.05). Simultaneous injections of GALANIN and MORPHINE causes more inhibitory effect on HPT axis activity (p<0.05).

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APA: Copy

HAGHNAZARI, FARZANEH, KHAZALI, HOMAYOUN, & TAGHVIYATI, SINA. (2016). GALANIN OR MORPHINE SIGNIFICANTLY DECREASED THYROID HORMONES CONCENTRATION AFTER INJECTIONS COMPARED TO BEFORE INJECTION. JOURNAL OF ANIMAL ENVIRONMENT, 8(2), 47-52. SID. https://sid.ir/paper/206672/en

Vancouver: Copy

HAGHNAZARI FARZANEH, KHAZALI HOMAYOUN, TAGHVIYATI SINA. GALANIN OR MORPHINE SIGNIFICANTLY DECREASED THYROID HORMONES CONCENTRATION AFTER INJECTIONS COMPARED TO BEFORE INJECTION. JOURNAL OF ANIMAL ENVIRONMENT[Internet]. 2016;8(2):47-52. Available from: https://sid.ir/paper/206672/en

IEEE: Copy

FARZANEH HAGHNAZARI, HOMAYOUN KHAZALI, and SINA TAGHVIYATI, “GALANIN OR MORPHINE SIGNIFICANTLY DECREASED THYROID HORMONES CONCENTRATION AFTER INJECTIONS COMPARED TO BEFORE INJECTION,” JOURNAL OF ANIMAL ENVIRONMENT, vol. 8, no. 2, pp. 47–52, 2016, [Online]. Available: https://sid.ir/paper/206672/en

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