EFFECT OF COMBINED IMMUNOTHERAPY IN SEVERE APLASTIC ANEMIA

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SHAHRIARAHMADI A.; MOGHIMI M.

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Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2001 | Volume:5 | Issue:1 Page(s): 9-17

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Information Journal Paper

Title

EFFECT OF COMBINED IMMUNOTHERAPY IN SEVERE APLASTIC ANEMIA

Author(s)

SHAHRIARAHMADI A. | MOGHIMI M. | Issue Writer Certificate

Keywords

APLASTIC ANEMIAQ3

ANTITHYMOCYTE GLOBULINQ3

CYCLOSPORINEQ4

Abstract

Bone marrow transplantation is the therapeutic method of choice in APLASTIC ANEMIA. Immunosuppressive agents can be used as a substitute in whom bone marrow transplantation is impossible. since marrow transplantation is not easily available in our country for many of the patients we studies the effects of combined immunotherapy as a choice in our patients.During 1997 to 1999 18 patients with APLASTIC ANEMIA, hospitalized in Taleghani hospital in Kermanshah received combined immunotherapy. the patients were 13-55 years old. Anti thymocyte globulin (ATG) 20 mg/Kg for 5 days, CYCLOSPORINE 6mg/Kg daily for 12-18 months, danazole 10mg/kg daily for 6 months & prednisolone 1mg/kg for 14 days were administered. the patient's response to therapy was monintored by WBC & platelet count (& increment) and hemoglobin measurement. regarding the recovery state they were divided in to three groups (complete recovery, relative recovery and weak response).One of the patients was dead with cerbral hemorrage due to thrombocytopenia.another one was not available for follow - up. of the remaining 16 who were followed( 6 to 30 months) 6 had complete response, 6 relative and 3 weak. Eatly complications were severe thrombocytopenia, leukopenia, hypertension, polyarthralgia, allergy, headache & covulsion. Our experice achieving 93.8% response suggests that combined immunotherapyis a good substitute for bone marrow transplantation in treatment of APLASTIC ANEMIA.

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APA: Copy

SHAHRIARAHMADI, A., & MOGHIMI, M.. (2001). EFFECT OF COMBINED IMMUNOTHERAPY IN SEVERE APLASTIC ANEMIA. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 5(1), 9-17. SID. https://sid.ir/paper/20857/en

Vancouver: Copy

SHAHRIARAHMADI A., MOGHIMI M.. EFFECT OF COMBINED IMMUNOTHERAPY IN SEVERE APLASTIC ANEMIA. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2001;5(1):9-17. Available from: https://sid.ir/paper/20857/en

IEEE: Copy

A. SHAHRIARAHMADI, and M. MOGHIMI, “EFFECT OF COMBINED IMMUNOTHERAPY IN SEVERE APLASTIC ANEMIA,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 5, no. 1, pp. 9–17, 2001, [Online]. Available: https://sid.ir/paper/20857/en

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