PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HASHEMIAN A.H.; HAJIZADEH EBRAHIM; KAZEMNEJAD ANOUSHIRAVAN; MESHKANI M.R.; ATRI M.; MAHDIPOUR P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2008 | Volume:12 | Issue:1 (36) Page(s): 59-70

Download Full-Text

Persian Verion

View:

1,108

Download:

Cites:

Information Journal Paper

Title

PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD

Author(s)

Keywords

PENETRANCEQ3

BREAST CANCERQ2

KIN-COHORT STUDYQ3

PIECEWISE WEIBULL MODELQ3

PIECEWISE EXPONENTIAL MODELQ3

Abstract

Introduction: The diagnosis of symptoms and the estimation of cancer risk in individuals are of great interest for research teams. Several methods developed for estimation of the risk of cancer in the individuals exposed to risk. Because of its capability to illustrate the correlation between genotype and phenotype, the Kin-Cohort Method has become a method of choice for many researchers. This study aims to employ a modified PIECEWISE WEIBULL MODEL for estimation of penterance in patients with BREAST CANCER characterized by BRCA1 and BRCA2 gene mutations carriers.Materials & Methods: The research follows a descriptive and analytical method. A set of data was simulated to resemble the true values. The simulated data set was analyzed using both Piecewise Exponential and PIECEWISE WEIBULL MODELs. EM algorithm and bootstrap sampling were employed for maximization. Akaike’s criterion was used to compare the two methods, and graphs of the PENETRANCE values were plotted to show the differences. To estimate the PENETRANCE of BRCA1/2 gene mutations, data was collected from the patients voluntarily referred to the Department of Medical Genetics and the Department of Cancer and Cytological Genetics of Medical School of Tehran University of Medical Sciences.Results: Results of the simulated data showed that the estimates of cancer PENETRANCE in the carriers and non-carriers in all age groups were closer to the default values in the Weibull model in comparison with the exponential model. The differences in Akaike’s criterion, 311 and 2753 for the non-carriers and carriers respectively in both models, showed a significant difference between the Exponential and Weibull models. Estimated PENETRANCE for the age groups below and over 50 among BRCA1/2 carriers for BREAST CANCER was 31.9% and 46.2% respectively.Conclusion: The knowledge of PENETRANCE is important in genetic counseling. Therefore methods capable of generating most accurate estimations are preferred. Results of the simulation revealed that the PIECEWISE WEIBULL MODEL is preferred for the estimation of PENETRANCE in Cancer Patients. The low value of the estimated PENETRANCE in this study can be attributed to the rare mutation in Iranian population. Establishment and use of a Kin-Cohort gene databank is proposed as a solution for preparation of screening programs and estimation of the PENETRANCE to help reduce the risk of cancer.

Cites

No record.

References

Cite

APA: Copy

HASHEMIAN, A.H., HAJIZADEH, EBRAHIM, KAZEMNEJAD, ANOUSHIRAVAN, MESHKANI, M.R., ATRI, M., & MAHDIPOUR, P.. (2008). PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 12(1 (36)), 59-70. SID. https://sid.ir/paper/20936/en

Vancouver: Copy

HASHEMIAN A.H., HAJIZADEH EBRAHIM, KAZEMNEJAD ANOUSHIRAVAN, MESHKANI M.R., ATRI M., MAHDIPOUR P.. PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2008;12(1 (36)):59-70. Available from: https://sid.ir/paper/20936/en

IEEE: Copy

A.H. HASHEMIAN, EBRAHIM HAJIZADEH, ANOUSHIRAVAN KAZEMNEJAD, M.R. MESHKANI, M. ATRI, and P. MAHDIPOUR, “PENETRANCE ESTIMATION IN BREAST CANCER PATIENTS VIA MODIFIED KIN-COHORT METHOD,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 12, no. 1 (36), pp. 59–70, 2008, [Online]. Available: https://sid.ir/paper/20936/en

Related Journal Papers