A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT

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REZVANIPOUR M.; SAFARI T.; ABBASNEZHAD M.

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Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2004 | Volume:11 | Issue:4 Page(s): 212-218

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Title

A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT

Author(s)

REZVANIPOUR M. | SAFARI T. | ABBASNEZHAD M. | Issue Writer Certificate

Keywords

CUNEIFORMIS NUCLEUSQ3

MORPHINEQ3

MUSCIMOLQ3

BICUCULLINEQ3

PAINQ2

Abstract

In the present study, the effects of intraCUNEIFORMIS NUCLEUS microinjection of gamma-aminobutyric acid A (GABAA) receptor agonist and antagonist on antinociception inducced by MORPHINE were investigated with formalin test in rat. IntraCUNEIFORMIS NUCLEUS microinjection of MORPHINE (10µgr/rat) and BICUCULLINE (50, 100 ng/rat) induced antinociception in the both first and second phases of formalin test. MUSCIMOL (25, 50 ,100 ngr/rat ) produced antinociception only in the second phase of formalin test. MORPHINE in combination with MUSCIMOL but not with BICUCULLINE elicited potentiation. The responses induced by MUSCIMOL were not affected by BICUCULLINE. The opioid receptor antagonist (naloxone) did not reduce the response induced by MUSCIMOL in the both first and second phases of formalin test. It may be concluded that central GABAA receptor stimulation induced antinociception in formalin test. However, the antinociception induced by GABAA receptor agonist may be partly mediated through nucleus cuneiformis opioid receptor mechanisms. The apparent antinociceptive effects of MUSCIMOL may be due to its leakage to rostal portion of Cnf and reduction in motion activity, so have no relation to its real antinociceptive effects.

Cites

EFFECT OF GABAB AGONIST AND ANTAGONIST MICROINJECTION INTO CUNEIFORMIS NUCLEUS (CNF) ON MORPHINE INDUCED ANTINOCICEPTION BY FORMALIN TEST IN RAT

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APA: Copy

REZVANIPOUR, M., SAFARI, T., & ABBASNEZHAD, M.. (2004). A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 11(4), 212-218. SID. https://sid.ir/paper/21/en

Vancouver: Copy

REZVANIPOUR M., SAFARI T., ABBASNEZHAD M.. A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2004;11(4):212-218. Available from: https://sid.ir/paper/21/en

IEEE: Copy

M. REZVANIPOUR, T. SAFARI, and M. ABBASNEZHAD, “A STUDY ON THE EFFECT OF INTRACUNEIFORMIS NUCLEUS MICROINJECTION OF GABAA RECEPTOR AGONIST AND ANTAGONIST ON ANTINOCICEPTIVE EFFECTS OF MORPHINE BY FORMALIN TEST IN RAT,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 4, pp. 212–218, 2004, [Online]. Available: https://sid.ir/paper/21/en

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