THE EFFECT OF NOSCAPINE ON CARRAGEENAN-INDUCED INFLAMMATION IN RAT

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KHAKPOUR MITRA; SHAFEI M.; ROSTAMI P.; SADOUGHI M.; MAHMOUDIAN M.

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Title

THE EFFECT OF NOSCAPINE ON CARRAGEENAN-INDUCED INFLAMMATION IN RAT

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Keywords

NOSCAPINEQ3

INFLAMMATIONQ2

CARRAGEENANQ4

RATQ4

Abstract

It has been recently reported that NOSCAPINE, an antitussive medicine, could antagonize bradykinin-induced responses. Concerning the role of bradykinin in inflammatory processes, the effect of NOSCAPINE on CARRAGEENAN-induced INFLAMMATION in RAT hind paw was investigated. Healthy male Wistar RATs were distributed into eight groups. Acute INFLAMMATION of hind paw was induced by subplantar injection of 0.1 ml of I% fresh suspension of CARRAGEENAN. NOSCAPINE at doses 0.5, 1, 2, 5 and 10 mg/Kg/BW and indomethacin (l0 mg/Kg/BW), as a known anti-inflammatory drug, were administered intraperitoneally an hour before CARRAGEENAN injection. The thickness of the hind paw was measured with caliper before and I, 2, and 3 hours after CARRAGEENAN injection. The RAT hind paw INFLAMMATION was decreased using NOSCAPINE. This effect was significant at second and third hours after CARRAGEENAN injection. The dose 5 mg/Kg/BW dosage three hours after CARRAGEENAN injection was the most effective one similar to anti-inflammatory effect of indomethacin at the same dosing time. This effect was diminished by using higher doses (10 mg/Kg/BW).

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APA: Copy

KHAKPOUR, MITRA, SHAFEI, M., ROSTAMI, P., SADOUGHI, M., & MAHMOUDIAN, M.. (2005). THE EFFECT OF NOSCAPINE ON CARRAGEENAN-INDUCED INFLAMMATION IN RAT. IRANIAN JOURNAL OF BIOLOGY, 18(2), 150-156. SID. https://sid.ir/paper/21009/en

Vancouver: Copy

KHAKPOUR MITRA, SHAFEI M., ROSTAMI P., SADOUGHI M., MAHMOUDIAN M.. THE EFFECT OF NOSCAPINE ON CARRAGEENAN-INDUCED INFLAMMATION IN RAT. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2005;18(2):150-156. Available from: https://sid.ir/paper/21009/en

IEEE: Copy

MITRA KHAKPOUR, M. SHAFEI, P. ROSTAMI, M. SADOUGHI, and M. MAHMOUDIAN, “THE EFFECT OF NOSCAPINE ON CARRAGEENAN-INDUCED INFLAMMATION IN RAT,” IRANIAN JOURNAL OF BIOLOGY, vol. 18, no. 2, pp. 150–156, 2005, [Online]. Available: https://sid.ir/paper/21009/en

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