ENHANCING OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS BY OPTIMIZATION OF DISSOLVED OXYGEN CONCENTRATION AND AGITATION RATE

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HAMEDI J.; MOGHIMI HAMID; ABBASI ROUH ELAHI A.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2009 | Volume:22 | Issue:2 Page(s): 259-270

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Information Journal Paper

Title

ENHANCING OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS BY OPTIMIZATION OF DISSOLVED OXYGEN CONCENTRATION AND AGITATION RATE

Author(s)

HAMEDI J. | MOGHIMI HAMID | ABBASI ROUH ELAHI A. | Issue Writer Certificate

Keywords

CLAVULANIC ACIDQ3

STREPTOMYCES CLAVULIGERUSQ2

DISSOLVED OXYGEN TENSIONQ3

AGITATION RATEQ3

Abstract

CLAVULANIC ACID (CA) is a useful antibiotic that is produced by STREPTOMYCES CLAVULIGERUS, in conventional agitated and aerated fermenters. This filamentous bacterium is strictly aerobic and very sensitive to shear force. DISSOLVED OXYGEN TENSION (DOT) level and mixing have remarkable effect on CA production. In the present study, the effect of various stirrer speeds and DOT concentrations on CA production by S. clavuligerus DSM738 was investigated. The results showed that the highest CA production (0.61g/l) was obtained when the DOT was controlled at 20% DOT. The highest CA production (0.85 g/l) was obtained when the AGITATION RATE was controlled at 700 rpm. When stirrer speed was increased than 700 rpm, the CA production was decreased drastically. In the medium containing more than 20% DOT, more growth of the strain was seen, but the concentration of the antibiotic was decreased. In the media with 200 rpm and DOT 10%, the growth of the strain and CA production was decreased drastically.

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References

سنجش میزان رشد Streptomyces vlavuligerus در محیط تولید کلاولانیک اسید با استفاده از معیار ثابت غلظت

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APA: Copy

HAMEDI, J., MOGHIMI, HAMID, & ABBASI ROUH ELAHI, A.. (2009). ENHANCING OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS BY OPTIMIZATION OF DISSOLVED OXYGEN CONCENTRATION AND AGITATION RATE. IRANIAN JOURNAL OF BIOLOGY, 22(2), 259-270. SID. https://sid.ir/paper/21072/en

Vancouver: Copy

HAMEDI J., MOGHIMI HAMID, ABBASI ROUH ELAHI A.. ENHANCING OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS BY OPTIMIZATION OF DISSOLVED OXYGEN CONCENTRATION AND AGITATION RATE. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2009;22(2):259-270. Available from: https://sid.ir/paper/21072/en

IEEE: Copy

J. HAMEDI, HAMID MOGHIMI, and A. ABBASI ROUH ELAHI, “ENHANCING OF CLAVULANIC ACID PRODUCTION BY STREPTOMYCES CLAVULIGERUS BY OPTIMIZATION OF DISSOLVED OXYGEN CONCENTRATION AND AGITATION RATE,” IRANIAN JOURNAL OF BIOLOGY, vol. 22, no. 2, pp. 259–270, 2009, [Online]. Available: https://sid.ir/paper/21072/en

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