EFFECTS OF SHIKONIN, A COMPONENT OF CHINESE HERBAL MEDICINE, ON ACTIVATION AND APOPTOSIS OF INFLAMMATED MICROGLIAL CELLS IN VITRO

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ALIZADEH MARYAM; SABOUNI FARZANEH; ABBASI SHAHSANAM; MOGHIMI ALI; HAGHBIN K.A.D.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2009 | Volume:22 | Issue:2 Page(s): 300-311

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Title

EFFECTS OF SHIKONIN, A COMPONENT OF CHINESE HERBAL MEDICINE, ON ACTIVATION AND APOPTOSIS OF INFLAMMATED MICROGLIAL CELLS IN VITRO

Author(s)

Keywords

SHIKONINQ2

ARNEBIA EUCHROMAQ3

MICROGLIAQ2

NOQ3

APOPTOSISQ3

LPSQ2

NEURODEGENERATIVEQ2

Abstract

SHIKONIN (b-alkannin) a red naphtoquinone pigment extracted from the groun rhizome of ARNEBIA EUCHROMA (Boraginaceae) which has been used in East Asia for treating burns, has anti-inflammatory and antitumor effects both in vitro and in vivo. In this study we evaluated the effects of SHIKONIN on activated MICROGLIA in vitro and analysis the changes of NO (Nitric oxide) level and percentage of APOPTOSIS in the presence or absence of LPS (Lipopolysaccharide). MICROGLIA, residential monocyte-lineaged cells in the central nervous system, can release a variety of factors including cytokines, chemokines, nitric oxide, etc. to regulate the communication among neuronal and other types of glial cells. When MICROGLIA are hyperactiveted due to a certain pathological imbalance, they may cause neuronal degeneration and inflammatory disease such as cerebral ischemia, Alzheimer' disease, prion disease, multiple sclerosis, parkinson' disease, AIDs dementia, trauma and others. Elevated level of NO produced with this cells in the CNS also are associated with the pathogenesis of neuroinflammatory and NEURODEGENERATIVE human disease. The crude plant extract of ARNEBIA EUCHROMA showed significant dose-dependent inhibition of NO production and APOPTOSIS of treatrd cells. The results showed that SHIKONIN at concentrations >&=10mg/ml induce APOPTOSIS and at concentrations beetwen 0.1-5mg/ml induce significant reduction in NO level as measured by Acridine orange/Ethidium bromide staning and Griess reagent, respectively. Thus, SHIKONIN may have clinical potential as anti-inflammatory therapeutics in NEURODEGENERATIVE disease.

Cites

THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES

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APA: Copy

ALIZADEH, MARYAM, SABOUNI, FARZANEH, ABBASI, SHAHSANAM, MOGHIMI, ALI, & HAGHBIN, K.A.D.. (2009). EFFECTS OF SHIKONIN, A COMPONENT OF CHINESE HERBAL MEDICINE, ON ACTIVATION AND APOPTOSIS OF INFLAMMATED MICROGLIAL CELLS IN VITRO. IRANIAN JOURNAL OF BIOLOGY, 22(2), 300-311. SID. https://sid.ir/paper/21073/en

Vancouver: Copy

ALIZADEH MARYAM, SABOUNI FARZANEH, ABBASI SHAHSANAM, MOGHIMI ALI, HAGHBIN K.A.D.. EFFECTS OF SHIKONIN, A COMPONENT OF CHINESE HERBAL MEDICINE, ON ACTIVATION AND APOPTOSIS OF INFLAMMATED MICROGLIAL CELLS IN VITRO. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2009;22(2):300-311. Available from: https://sid.ir/paper/21073/en

IEEE: Copy

MARYAM ALIZADEH, FARZANEH SABOUNI, SHAHSANAM ABBASI, ALI MOGHIMI, and K.A.D. HAGHBIN, “EFFECTS OF SHIKONIN, A COMPONENT OF CHINESE HERBAL MEDICINE, ON ACTIVATION AND APOPTOSIS OF INFLAMMATED MICROGLIAL CELLS IN VITRO,” IRANIAN JOURNAL OF BIOLOGY, vol. 22, no. 2, pp. 300–311, 2009, [Online]. Available: https://sid.ir/paper/21073/en

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