INVERSE MINIEMULSION METHOD FOR SYNTHESIS OF GELATIN NANOPARTICLES IN PRESENCE OF CDI/NHS AS A NON-TOXIC CROSS-LINKING SYSTEM

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ZINATLOO AJABSHIR SAHAR; TAHERI QAZVINI NADER

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Journal: JOURNAL OF NANOSTRUCTURES Year:2014 | Volume:4 | Issue:3 Page(s): 267-275

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Title

INVERSE MINIEMULSION METHOD FOR SYNTHESIS OF GELATIN NANOPARTICLES IN PRESENCE OF CDI/NHS AS A NON-TOXIC CROSS-LINKING SYSTEM

Author(s)

ZINATLOO AJABSHIR SAHAR | TAHERI QAZVINI NADER | Issue Writer Certificate

Keywords

GELATIN NANOPARTICLESQ2

WATER SOLUBLE CARBODIIMIDEQ2

NON-TOXIC CROSS-LINKING SYSTEMQ2

INTRINSIC VISCOSITYQ2

Abstract

In this research, GELATIN NANOPARTICLES were synthesized via inverse miniemulsion method by employing a mixture of a WATER SOLUBLE CARBODIIMIDE (CDI) and N-hydroxysuccinimide (NHS) as a NON-TOXIC CROSS-LINKING SYSTEM. The GELATIN NANOPARTICLES were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutaraldehyde (GA) as the most commonly utilized cross-linking agent. The results showed the formation of more homogeneous nanoparticles with smaller size when CDI/NHS used as cross-linking agent under the same synthesis condition. Moreover, dilute solution viscosimetry experiments confirmed the stability of the nanoparticles under various physicochemical conditions. The differences in the characteristics of CDI/NHS and GA cross-linked nanoparticles were ascribed to the different nature of network formation using the two cross-linking agents. Generally, these results suggested CDI/NHS cross-linked gelatin nanoprticles as an interesting candidate for drug delivery application.

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APA: Copy

ZINATLOO AJABSHIR, SAHAR, & TAHERI QAZVINI, NADER. (2014). INVERSE MINIEMULSION METHOD FOR SYNTHESIS OF GELATIN NANOPARTICLES IN PRESENCE OF CDI/NHS AS A NON-TOXIC CROSS-LINKING SYSTEM. JOURNAL OF NANOSTRUCTURES, 4(3), 267-275. SID. https://sid.ir/paper/210924/en

Vancouver: Copy

ZINATLOO AJABSHIR SAHAR, TAHERI QAZVINI NADER. INVERSE MINIEMULSION METHOD FOR SYNTHESIS OF GELATIN NANOPARTICLES IN PRESENCE OF CDI/NHS AS A NON-TOXIC CROSS-LINKING SYSTEM. JOURNAL OF NANOSTRUCTURES[Internet]. 2014;4(3):267-275. Available from: https://sid.ir/paper/210924/en

IEEE: Copy

SAHAR ZINATLOO AJABSHIR, and NADER TAHERI QAZVINI, “INVERSE MINIEMULSION METHOD FOR SYNTHESIS OF GELATIN NANOPARTICLES IN PRESENCE OF CDI/NHS AS A NON-TOXIC CROSS-LINKING SYSTEM,” JOURNAL OF NANOSTRUCTURES, vol. 4, no. 3, pp. 267–275, 2014, [Online]. Available: https://sid.ir/paper/210924/en

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