EFFECT OF HYPOTHYROIDISM INDUCED BY PROPILTIOURACIL (PTU) ON SERUM LEVELS OF COPPER AND ZINC IN RAT

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YOUSOFVAND N.; SHIRZADI BEHFAR M.; YAVARI F.; DEZFOOLINEZHAD S.; KABOODI R.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2010 | Volume:23 | Issue:6 Page(s): 900-908

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Title

EFFECT OF HYPOTHYROIDISM INDUCED BY PROPILTIOURACIL (PTU) ON SERUM LEVELS OF COPPER AND ZINC IN RAT

Author(s)

Keywords

HYPOTHYROIDISMQ3

PROPYLTHIOURACILQ3

ZINC (ZN)Q2

COPPER (CU)Q2

SERUMQ3

Abstract

The thyroid gland is one of the important endocrine glands of the body that plays vital roles in the regulation of metabolism and growth. Thyroid dysfunctions are considered as one of the most important endocrinopathies. Trace elements as Zinc (Zn) and Copper (Cu) play an important role in the properly performance of the most body functions. Thus a small change of these elements causes main disruptions in the structure and function of body. The aim of the present study is hypothyroid induction and investigation of its effect on SERUM level of trace two elements, Zn and Cu. Twenty-one male rats weighting 135-145g, divided into three groups. The control group received drinking water; HYPOTHYROIDISM groups received two doses of PROPYLTHIOURACIL (PTU), low dose treatment group, received 1mg/100ml in drinking water and high dose treatment group, received 10mg/100ml in drinking water, for 60 days.At the end of experiment the animals were sacrificed, SERUM samples were obtained and thyroid gland was removed. SERUM hormones level of T3 and T4 was determined with radioimmunoassay and SERUM levels of Zn and Cu was determined with graphite atomic absorption spectrophotometer. Results showed that the SERUM level of T4 was reduced significantly in treatment groups compared to control. The SERUM levels of Zn compared to the control group reduced but the SERUM levels of Cu increased. Thus, PTU by induction of HYPOTHYROIDISM and changing in the level of T3 and T4 causes changes in homeostasis of Zn and Cu elements in body.

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APA: Copy

YOUSOFVAND, N., SHIRZADI BEHFAR, M., YAVARI, F., DEZFOOLINEZHAD, S., & KABOODI, R.. (2010). EFFECT OF HYPOTHYROIDISM INDUCED BY PROPILTIOURACIL (PTU) ON SERUM LEVELS OF COPPER AND ZINC IN RAT. IRANIAN JOURNAL OF BIOLOGY, 23(6), 900-908. SID. https://sid.ir/paper/21162/en

Vancouver: Copy

YOUSOFVAND N., SHIRZADI BEHFAR M., YAVARI F., DEZFOOLINEZHAD S., KABOODI R.. EFFECT OF HYPOTHYROIDISM INDUCED BY PROPILTIOURACIL (PTU) ON SERUM LEVELS OF COPPER AND ZINC IN RAT. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2010;23(6):900-908. Available from: https://sid.ir/paper/21162/en

IEEE: Copy

N. YOUSOFVAND, M. SHIRZADI BEHFAR, F. YAVARI, S. DEZFOOLINEZHAD, and R. KABOODI, “EFFECT OF HYPOTHYROIDISM INDUCED BY PROPILTIOURACIL (PTU) ON SERUM LEVELS OF COPPER AND ZINC IN RAT,” IRANIAN JOURNAL OF BIOLOGY, vol. 23, no. 6, pp. 900–908, 2010, [Online]. Available: https://sid.ir/paper/21162/en

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