THE FUNCTION OF SNP AT -1171 MMP-3 PROMOTERS IN SUSCEPTIBILITY TO BREAST CANCER IN ISFAHAN POPULATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOTEVALIBASHI MAJID; HOJATI ZOHREH; HAJI HOSSEINI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF BIOLOGY Year:2008 | Volume:20 | Issue:4 Page(s): 399-405

Download Full-Text

Persian Verion

View:

1,016

Download:

Cites:

Information Journal Paper

Title

THE FUNCTION OF SNP AT -1171 MMP-3 PROMOTERS IN SUSCEPTIBILITY TO BREAST CANCER IN ISFAHAN POPULATION

Author(s)

MOTEVALIBASHI MAJID | HOJATI ZOHREH | HAJI HOSSEINI S. | Issue Writer Certificate

Keywords

MATRIX METALLOPROTEINASEQ3

SINGLE NUCLEOTIDE POLYMORPHISMQ3

METASTASISQ3

Abstract

The MATRIX METALLOPROTEINASEs (MMPs), a family of proteolytic enzymes that degrade different components of the extra cellular matrix (ECM), play important roles in tumor development and invasion. MMP3 also known as stromelysin-1, has been shown to influence tumor initiation and progression (5 and 23). A single adenine insertion/deletion polymorphism (5A/6A) at position -1171 MMP3 gene promoter regions causes the elevation of the transcriptional level and local expression of MMP3. This study is about 5A/6A polymorphism role on susceptibility and METASTASIS in breast cancer. The MMP3 SNP was genotyped by polymerase chain reaction- restriction fragment length polymorphism analysis in 120 cancer patients and 60 controls in Isfahan. The breast cancer group was divided into a group without METASTASIS (M-) and a group that they had developed METASTASIS (M+). The 5A allele was more prevalent in the M+ group than in control (p= 95% OR= 2.91 CI= 95%).The difference between M- patients and controls was not significant. Regarding to our results, we suggest that the risk of breast cancer in progressive position and METASTASIS has been increased in homo and heterozygous carriers of the 5A allele.

Cites

No record.

References

No record.

Cite

APA: Copy

MOTEVALIBASHI, MAJID, HOJATI, ZOHREH, & HAJI HOSSEINI, S.. (2008). THE FUNCTION OF SNP AT -1171 MMP-3 PROMOTERS IN SUSCEPTIBILITY TO BREAST CANCER IN ISFAHAN POPULATION. IRANIAN JOURNAL OF BIOLOGY, 20(4), 399-405. SID. https://sid.ir/paper/21286/en

Vancouver: Copy

MOTEVALIBASHI MAJID, HOJATI ZOHREH, HAJI HOSSEINI S.. THE FUNCTION OF SNP AT -1171 MMP-3 PROMOTERS IN SUSCEPTIBILITY TO BREAST CANCER IN ISFAHAN POPULATION. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2008;20(4):399-405. Available from: https://sid.ir/paper/21286/en

IEEE: Copy

MAJID MOTEVALIBASHI, ZOHREH HOJATI, and S. HAJI HOSSEINI, “THE FUNCTION OF SNP AT -1171 MMP-3 PROMOTERS IN SUSCEPTIBILITY TO BREAST CANCER IN ISFAHAN POPULATION,” IRANIAN JOURNAL OF BIOLOGY, vol. 20, no. 4, pp. 399–405, 2008, [Online]. Available: https://sid.ir/paper/21286/en

Related Journal Papers